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Keratin 17 (KRT17) antibody
|Synonyms||PC, K17, PC2, PCHC1, Krt1-17, MGC159887, Ka17, KRT17, krt16|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|2 references available|
|Price||426.25 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||Purified recombinant fragment of CK17 expressed in E. Coli.|
CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Synonyms: PC, K17, PC2, PCHC1, KRT17
Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Preservative||0.03% sodium azide.|
|Storage||Store at 4°C, for long term storage, store at -20°C.|
|Restrictions||For Research Use only|
Leigh, Navsaria, Purkis et al.: "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro." in: The British journal of dermatology, Vol. 133, Issue 4, pp. 501-11, 1995 (PubMed).
van de Rijn, Perou, Tibshirani et al.: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." in: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, 2002 (PubMed).