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Details for Product No. ABIN965900

Keratin 17 (KRT17) antibody

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Antigen
Synonyms PC, K17, PC2, PCHC1, Krt1-17, Ka17, si:dkeyp-113d7.7, KRT17, krt16
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 2 references available
Catalog no. ABIN965900
Quantity 0.1 mL
Price
426.25 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen Purified recombinant fragment of CK17 expressed in E. Coli.
Clone 3B12
Isotype IgG2b
Purification Ascitic fluid
Alternative Name CK17
Background CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Synonyms: PC, K17, PC2, PCHC1, KRT17
Molecular Weight 49kDa
Gene ID 3872
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Preservative Sodium azide
Storage 4 °C
Product cited in: Leigh, Navsaria, Purkis et al.: "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro." in: The British journal of dermatology, Vol. 133, Issue 4, pp. 501-11, 1995 (PubMed).

van de Rijn, Perou, Tibshirani et al.: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." in: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, 2002 (PubMed).

Alternatives for antigen "Keratin 17 (KRT17)", type "Antibodies"
Hosts (82), (64), (4)
Reactivities (130), (72), (48), (13), (13), (1), (1), (1)
Applications (107), (82), (41), (37), (25), (23), (22), (20), (12), (11), (7), (6), (2), (1)
Conjugates (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (16), (12), (4), (4), (2), (1)
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