Keratin 17 (KRT17) antibody

Details for Product No. ABIN965900
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Antigen
Synonyms K17, PC, PC2, PCHC1, Ka17, Krt1-17, si:dkeyp-113d7.7, KRT17, krt16
Reactivity
Human
(154), (77), (55), (14), (13), (1), (1), (1)
Host
Mouse
(97), (68), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
(129), (83), (58), (46), (36), (36), (36), (20), (15), (6), (3), (2)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN965900
440.00 $
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Immunogen Purified recombinant fragment of CK17 expressed in E. Coli.
Clone 3B12
Isotype IgG2b
Purification Ascitic fluid
Alternative Name CK17
Background CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Synonyms: PC, K17, PC2, PCHC1, KRT17
Molecular Weight 49kDa
Gene ID 3872
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Leigh, Navsaria, Purkis et al.: "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro." in: The British journal of dermatology, Vol. 133, Issue 4, pp. 501-11, 1995 (PubMed).

van de Rijn, Perou, Tibshirani et al.: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." in: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, 2002 (PubMed).

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