You are viewing an incomplete version of our website. Please click to reload the website as full version.

Decay Accelerating Factor 2 (DAF2) (C-Term) antibody

Details for Product No. ABIN965970, Supplier: Log in to see
  • AI323748
  • Cd55b
  • Daf
  • Daf-TM
  • TM-DAF
  • decay accelerating factor 2
  • Protein DAF-2
  • Daf2
  • daf-2
Caenorhabditis elegans (C. elegans)
Immunohistochemistry (IHC)
Log in to see
Supplier Product No.
Log in to see

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Caenorhabditis elegans daf-2(Abnormal dauer formation protein 2)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name Daf-2
Background The daf-2 is an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Lifespan regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Yu, Larsen: "DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs." in: Journal of molecular biology, Vol. 314, Issue 5, pp. 1017-28, 2001 (PubMed).

Tissenbaum, Ruvkun: "An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans." in: Genetics, Vol. 148, Issue 2, pp. 703-17, 1998 (PubMed).

Kimura, Tissenbaum, Liu, Ruvkun: "daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 942-6, 1997 (PubMed).

Ogg, Paradis, Gottlieb, Patterson, Lee, Tissenbaum, Ruvkun: "The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans." in: Nature, Vol. 389, Issue 6654, pp. 994-9, 1997 (PubMed).