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Decay Accelerating Factor 2 (DAF2) (C-Term) antibody

Details for Product No. ABIN965970
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Antigen
Synonyms AI323748, Cd55b, Daf, Daf-TM, TM-DAF
Epitope
C-Term
(1)
Reactivity
Caenorhabditis elegans (C. elegans)
(1)
Host
Rabbit
(1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
(1)
Pubmed 4 references available
Quantity 0.1 mg
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Availability Will be delivered in 5 to 7 Business Days
Catalog No. ABIN965970
397.38 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Caenorhabditis elegans daf-2(Abnormal dauer formation protein 2)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name Daf-2
Background The daf-2 is an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Lifespan regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Kimura, Tissenbaum, Liu et al.: "daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 942-6, 1997 (PubMed).

Ogg, Paradis, Gottlieb et al.: "The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans." in: Nature, Vol. 389, Issue 6654, pp. 994-9, 1997 (PubMed).

Tissenbaum, Ruvkun: "An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans." in: Genetics, Vol. 148, Issue 2, pp. 703-17, 1998 (PubMed).

Yu, Larsen: "DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs." in: Journal of molecular biology, Vol. 314, Issue 5, pp. 1017-28, 2001 (PubMed).

Hosts (1)
Reactivities (1)
Applications (1)
Epitopes (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN965970
397.38 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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