DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (N-Term) antibody

Details for Product No. ABIN965986
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Antigen
Synonyms RIG-I, RIGI, RLR-1, 6430573D20Rik, C330021E21, RHIV-1, RIG-1
Epitope
N-Term
(13), (13), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(90), (42), (24), (24), (24), (24), (1)
Host
Rabbit
(79), (7), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunohistochemistry (IHC)
(53), (34), (30), (26), (18), (4), (3), (2), (2), (1), (1)
Pubmed 8 references available
Catalog no. ABIN965986
Quantity 0.1 mg
Price
452.38 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DDX58(Probable ATP-dependent RNA helicase DDX58)(DEAD-box protein 58)
Alternative Name DDX58
Background DDX58(Probable ATP-dependent RNA helicase DDX58)(DEAD-box protein 58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). DDX58 detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). DDX58 is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. DDX58 is maintained as a monomer in an autoinhibited state. Upon viral dsRNA binding and conformation shift, homomultimerizes and interacts with MAVS. DDX58 interacts with DHX58/LGP2, IKBKE, TBK1 and TMEM173/STING. DDX58 is present in vascular smooth cells. The repressor domain controls homomultimerization and interaction with MAVS. The helicase domain is responsible for dsRNA recognition. The 2 CARD domains are responsible for interaction with and signaling through MAVS. DDX58 is conjugated to ubiquitin-like protein ISG15 upon IFN-beta stimulation. DDX58 belongs to the helicase family and contains 2 CARD domains, 1 helicase ATP-binding domain and 1 helicase C-terminal domain.
Synonyms: RIG-1 (Retinoic acid-inducible gene 1 protein)
Research Area Immunology, Chromatin Binding Proteins, DNA/RNA, Transcription Factors
Restrictions For Research Use only
Product cited in: Imaizumi, Aratani, Nakajima et al.: "Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2." in: Biochemical and biophysical research communications, Vol. 292, Issue 1, pp. 274-9, 2002 (PubMed).

Cui, Imaizumi, Yoshida et al.: "Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 82, Issue 3, pp. 401-5, 2004 (PubMed).

Yoneyama, Kikuchi, Natsukawa et al.: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004 (PubMed).

Sumpter, Loo, Foy et al.: "Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I." in: Journal of virology, Vol. 79, Issue 5, pp. 2689-99, 2005 (PubMed).

Seth, Sun, Ea et al.: "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3." in: Cell, Vol. 122, Issue 5, pp. 669-82, 2005 (PubMed).

Xu, Wang, Han et al.: "VISA is an adapter protein required for virus-triggered IFN-beta signaling." in: Molecular cell, Vol. 19, Issue 6, pp. 727-40, 2005 (PubMed).

Huang, Liu, Xu et al.: "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways." in: The EMBO journal, Vol. 24, Issue 23, pp. 4018-28, 2005 (PubMed).

"Outbreak news. Rift Valley fever, Sudan." in: Relevé épidémiologique hebdomadaire / Section d'hygiène du Secrétariat de la Société des Nations = Weekly epidemiological record / Health Section of the Secretariat of the League of Nations, Vol. 82, Issue 46, pp. 401-2, 2007 (PubMed).

Hosts (79), (7), (6), (2)
Reactivities (90), (42), (24), (24), (24), (24), (1)
Applications (53), (34), (30), (26), (18), (4), (3), (2), (2), (1), (1)
Conjugates (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (13), (13), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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