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Glypican 1 (GPC1) (C-Term) antibody

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Synonyms gpc1, zgc:63947, GPC1, Glypican-1, glypican, AI462976, HSPG M12, HSPGM12
(8), (8), (5), (5), (5), (3), (2), (2), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(68), (38), (24), (2), (2), (2)
(59), (18), (2)
(7), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(58), (41), (14), (11), (11), (7), (7), (6), (5), (5), (1), (1), (1)
Pubmed 9 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human GPC1(Glypican-1 precursor)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name GPC1 (GPC1 Antibody Abstract)
Background GPC1(Glypican-1) is a cell surface proteoglycan that bears heparan sulfate. The protein is attached to the membrane by a GPI-anchor. This cell-associated glypican is further processed to give rise to a medium-released species. The glypican-1 is required for efficient TGF-beta1 signaling in pancreatic cancer cells. The syndecan-1 and glypican-1 have roles in progression of ovarian cancer. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Davies, Blackhall, Shanks et al.: "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 15, pp. 5178-86, 2004 (PubMed).

Background publications Su, Meyer, Nandini et al.: "Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells." in: The American journal of pathology, Vol. 168, Issue 6, pp. 2014-26, 2006 (PubMed).

Polityko, Maltseva, Rumyantseva et al.: "Two further AHO-like syndrome patients with deletion of glypican 1 gene region in 2q37.2-q37.3." in: International journal of molecular medicine, Vol. 14, Issue 6, pp. 977-9, 2004 (PubMed).

Belting, Mani, Jönsson et al.: "Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide." in: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 47181-9, 2003 (PubMed).

Ding, Mani, Cheng et al.: "Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols." in: The Journal of biological chemistry, Vol. 277, Issue 36, pp. 33353-60, 2002 (PubMed).

Alvarez, Fadic, Brandan: "Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy." in: Journal of cellular biochemistry, Vol. 85, Issue 4, pp. 703-13, 2002 (PubMed).

Matsuda, Maruyama, Guo et al.: "Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells." in: Cancer research, Vol. 61, Issue 14, pp. 5562-9, 2001 (PubMed).

Ronca, Andersen, Paech et al.: "Characterization of Slit protein interactions with glypican-1." in: The Journal of biological chemistry, Vol. 276, Issue 31, pp. 29141-7, 2001 (PubMed).

David, Lories, Decock et al.: "Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts." in: The Journal of cell biology, Vol. 111, Issue 6 Pt 2, pp. 3165-76, 1991 (PubMed).

Catalog No. ABIN966218
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