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Glypican 1 (GPC1) (C-Term) antibody

Details for Product No. ABIN966218, Supplier: Login to see
Antigen
  • gpc1
  • zgc:63947
  • GPC1
  • Glypican-1
  • glypican
  • AI462976
  • HSPG M12
  • HSPGM12
Epitope
C-Term
8
8
5
5
5
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
68
38
24
2
2
2
Host
Rabbit
59
18
2
Clonality
Polyclonal
Conjugate
Un-conjugated
7
5
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
58
41
14
11
11
7
7
6
5
5
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human GPC1(Glypican-1 precursor)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name GPC1 (GPC1 Antibody Abstract)
Background GPC1(Glypican-1) is a cell surface proteoglycan that bears heparan sulfate. The protein is attached to the membrane by a GPI-anchor. This cell-associated glypican is further processed to give rise to a medium-released species. The glypican-1 is required for efficient TGF-beta1 signaling in pancreatic cancer cells. The syndecan-1 and glypican-1 have roles in progression of ovarian cancer. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
Pathways
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Davies, Blackhall, Shanks et al.: "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 15, pp. 5178-86, 2004 (PubMed).

Background publications Su, Meyer, Nandini et al.: "Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells." in: The American journal of pathology, Vol. 168, Issue 6, pp. 2014-26, 2006 (PubMed).

Polityko, Maltseva, Rumyantseva et al.: "Two further AHO-like syndrome patients with deletion of glypican 1 gene region in 2q37.2-q37.3." in: International journal of molecular medicine, Vol. 14, Issue 6, pp. 977-9, 2004 (PubMed).

Belting, Mani, Jönsson et al.: "Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide." in: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 47181-9, 2003 (PubMed).

Ding, Mani, Cheng et al.: "Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols." in: The Journal of biological chemistry, Vol. 277, Issue 36, pp. 33353-60, 2002 (PubMed).

Alvarez, Fadic, Brandan: "Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy." in: Journal of cellular biochemistry, Vol. 85, Issue 4, pp. 703-13, 2002 (PubMed).

Matsuda, Maruyama, Guo et al.: "Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells." in: Cancer research, Vol. 61, Issue 14, pp. 5562-9, 2001 (PubMed).

Ronca, Andersen, Paech et al.: "Characterization of Slit protein interactions with glypican-1." in: The Journal of biological chemistry, Vol. 276, Issue 31, pp. 29141-7, 2001 (PubMed).

David, Lories, Decock et al.: "Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts." in: The Journal of cell biology, Vol. 111, Issue 6 Pt 2, pp. 3165-76, 1991 (PubMed).