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Gremlin 1 (GREM1) (C-Term) antibody

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Antigen
Synonyms	Cktsf1b1, Drm, Grem, ld, drm, gremlin-1, CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2, cktsf1b1, grem1, MGC136702, zgc:136702, GREM1, pig2, dand2, ihg-2, gremlin
Epitope	Alternatives C-Term (8), (4), (2), (2), (2), (1), (1), (1)
Reactivity	Alternatives Human (41), (30), (21), (20), (17), (17), (17), (1)
Host	Alternatives Rabbit (50), (1), (1)
Clonality	Polyclonal
Conjugate	Alternatives Un-conjugated (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application	Alternatives Western Blotting (WB) (35), (23), (15), (12), (9), (6), (3), (1), (1)
	4 references available

Catalog no.	ABIN966222
Quantity	100 µg
Price	316.25 $ Plus shipping costs $45.00

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Product details

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Target Details

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Alternative Name

Gremlin-1

Background

Gremlin, also known as Drm, is a highly conserved 20. 7-kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. And Gremlin is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. Gremlin 1 (GREM 1) is known for its antagonistic reaction with BMPs in the TGF beta signaling pathway. This gene inhibits BMP-2, BMP-4, and BMP-7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH (Its binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to be located between residues 1-67). Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.

Application Details

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Handling

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References

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Alternatives

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Alternatives for antigen "Gremlin 1 (GREM1)", type "Antibodies"

Hosts	(50), (1), (1)
Reactivities	(41), (30), (21), (20), (17), (17), (17), (1)
Applications	(35), (23), (15), (12), (9), (6), (3), (1), (1)
Conjugates	(4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes	(8), (4), (2), (2), (2), (1), (1), (1)

Immunogen	A synthetic peptide corresponding to a sequence at the C-terminal of human Gremlin 1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
Isotype	IgG
Cross-Reactivity	Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details)	No cross reactivity with other proteins.
Characteristics	Rabbit IgG polyclonal antibody for Gremlin-1 (GREM1) detection. Tested with WB in Human, Mouse, Rat.

Format	Lyophilized
Reconstitution	Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer	Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative	Sodium azide, Thimerosal (Merthiolate)
Handling Advice	Avoid repeated freezing and thawing.
Storage	4 °C/-20 °C
Storage Comment	At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.