Gremlin 1 (GREM1) (C-Term) antibody

Antigen: Gremlin 1 (GREM1)

Synonyms: ld, Drm, Cktsf1b1, drm, GREM1, grem1, MGC136702, zgc:136702, DRM, PIG2, DAND2, IHG-2, GREMLIN, CKTSF1B1, MGC126660, pig2, dand2, ihg-2, gremlin

Binding Site: C-Term

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human, Mouse (Murine), Rat (Rattus), Rabbit

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN966222

Additional Information

Alternative name: Gremlin 1

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human Gremlin 1, identical to the related rat and mouse sequence.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: Gremlin, also known as Drm, is a highly conserved 20.7-kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein.1,2 Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. And Gremlin is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. Gremlin 1 (GREM 1) is known for its antagonistic reaction with BMPs in the TGF beta signaling pathway. This gene inhibits BMP-2, BMP-4, and BMP-7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development.3 Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH(Its binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to be located between residues 1-67). Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.4

Application Details

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Research Area: Stem Cells, Extracellular Matrix

Restrictions: For Research Use only

Publications

Product: Gazzerro, Pereira, Jorgetti et al.: "Skeletal overexpression of gremlin impairs bone formation and causes osteopenia." in: Endocrinology, Vol. 146, Issue 2, pp. 655-65, 2005 (PubMed).

Sox: "Office-based testing for fecal occult blood: do only in case of emergency." in: Annals of internal medicine, Vol. 142, Issue 2, pp. 146-8, 2005 (PubMed).

Namkoong, Shin, Kim et al.: "The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein." in: BMC cancer, Vol. 6, pp. 74, 2006 (PubMed).

Stabile, Mitola, Moroni et al.: "Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor." in: Blood, Vol. 109, Issue 5, pp. 1834-40, 2007 (PubMed).