Gremlin 1 (GREM1) (C-Term) antibody

Details for Product No. ABIN966222
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Antigen
Synonyms grem1, MGC136702, zgc:136702, GREM1, drm, pig2, dand2, ihg-2, gremlin, Cktsf1b1, Drm, Grem, ld, gremlin-1, CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2, cktsf1b1
Epitope
C-Term
(21), (8), (8), (6), (6), (6), (4), (3), (2), (1), (1), (1), (1)
Reactivity
Human
(63), (32), (18), (16), (12), (12), (2)
Host
Rabbit
(70), (10), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(61), (49), (23), (13), (10), (9), (9), (1)
Pubmed 4 references available
Quantity 100 μg
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Catalog No. ABIN966222
330.00 $
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human Gremlin 1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Gremlin-1 (GREM1) detection. Tested with WB in Human, Mouse, Rat.
Alternative Name Gremlin-1
Background Gremlin, also known as Drm, is a highly conserved 20. 7-kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. And Gremlin is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. Gremlin 1 (GREM 1) is known for its antagonistic reaction with BMPs in the TGF beta signaling pathway. This gene inhibits BMP-2, BMP-4, and BMP-7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH (Its binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to be located between residues 1-67). Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Gazzerro, Pereira, Jorgetti et al.: "Skeletal overexpression of gremlin impairs bone formation and causes osteopenia." in: Endocrinology, Vol. 146, Issue 2, pp. 655-65, 2005 (PubMed).

Sox: "Office-based testing for fecal occult blood: do only in case of emergency." in: Annals of internal medicine, Vol. 142, Issue 2, pp. 146-8, 2005 (PubMed).

Namkoong, Shin, Kim et al.: "The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein." in: BMC cancer, Vol. 6, pp. 74, 2006 (PubMed).

Stabile, Mitola, Moroni et al.: "Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor." in: Blood, Vol. 109, Issue 5, pp. 1834-40, 2007 (PubMed).

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