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Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibody

Details for Product No. ABIN966249
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Antigen
Synonyms TEF1, HAUSP, Hausp, 2210010O09Rik, AA409944, AA617399, AU019296, AW548146, C80752, UBP, CG1490, Dmel\\CG1490, USP7
Reactivity
Human
(79), (21), (21), (16), (16), (15), (13), (2), (2), (1), (1), (1)
Host
Mouse
(59), (21), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(71), (36), (21), (13), (11), (10), (6), (4), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Options
Shipping to United States (Change)
Availability Will be delivered in 5 to 7 Business Days
Catalog No. ABIN966249
426.25 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of human HAUSP expressed in E. Coli.
Clone 5F11
Isotype IgG1
Purification Ascitic fluid
Alternative Name HAUSP
Background USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Synonyms: TEF1, HAUSP, USP7
Molecular Weight 128kDa
Gene ID 7874
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: MILLER: "Observations on a case of probable bone marrow anthracosis." in: Blood, Vol. 14, pp. 1350-3 (PubMed).

Abély: "[Treatment of airway inflammation in cystic fibrosis]." in: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Vol. 14, Issue 11, pp. 1350-5, 2007 (PubMed).

Daubeuf, Singh, Tan et al.: "HSV ICP0 recruits USP7 to modulate TLR-mediated innate response." in: Blood, Vol. 113, Issue 14, pp. 3264-75, 2009 (PubMed).

Kotoula, Krikelis, Karavasilis et al.: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." in: BMC cancer, Vol. 12, Issue 1, pp. 342, 2012 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN966249
426.25 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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