Kelch-Like 15 (Drosophila) (KLHL15) (C-Term) antibody

Antigen: Kelch-Like 15 (Drosophila) (KLHL15)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine)

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966458

Additional Information

Alternative name: KLHL15

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human KLHL15 ( Kelch-like protein 15)

Description: KLHL15 ( Kelch-like protein 15) is a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-abrac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. KLHL15 is probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. KLHL15 interacts with CUL3 and contains 1 BACK (BTB/Kelch associated) domain, 1 BTB (POZ) domain and 5 Kelch repeats.
Synonyms: KIAA1677

Application Details

Research Area: Proteolysis / Ubiquitin

Restrictions: For Research Use only

Publications

Product: Nagase, Kikuno, Hattori et al.: "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 6, pp. 347-55, 2001 (PubMed).

Furukawa, He, Borchers et al.: "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases." in: Nature cell biology, Vol. 5, Issue 11, pp. 1001-7, 2003 (PubMed).

Yoshida: "Identification and characterization of a novel kelch-like gene KLHL15 in silico." in: Oncology reports, Vol. 13, Issue 6, pp. 1133-7, 2005 (PubMed).

Bechtel, Rosenfelder, Duda et al.: "The full-ORF clone resource of the German cDNA Consortium." in: BMC genomics, Vol. 8, pp. 399, 2008 (PubMed).