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Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (Middle Region) antibody

Details for Product No. ABIN967211, Supplier: Login to see
Antigen
  • si:dkey-9e15.2
  • VR.5'sv
  • Vr1
  • Vr1l1
  • VR1
  • OTRPC1
  • TRPV1alpha
  • TRPV1beta
  • VR-1
Epitope
Middle Region
30
25
13
13
10
7
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
102
67
42
7
3
3
3
3
2
1
Host
Rabbit
143
11
8
7
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
109
99
33
16
13
11
8
8
6
3
2
Supplier
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Immunogen A synthetic peptide corresponding to a sequence in the middle region of human TRPV1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Transient receptor potential cation channel subfamily V member 1 ( TRPV1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Alternative Name Transient receptor potential cation channel subfamily V member 1 (TRPV1) (TRPV1 Antibody Abstract)
Background The transient receptor potential cation channel, subfamily V, member 1 (TRPV1), also known as the capsaicin receptor is a protein which in humans is encoded by the TRPV1 gene. TRPV1 (also called Vanilloid receptor type 1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary afferents, TRPV1 is also expressed in the CNS. Cui M et al. (2006) demonstrate that TRPV1 receptors in the CNS play an important role in pain mediated by central sensitization. And the significant CNS penetration is necessary for a TRPV1 antagonist to produce broad-spectrum analgesia. And TRPV1 also participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.
Pathways
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Cui, Honore, Zhong et al.: "TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 37, pp. 9385-93, 2006 (PubMed).

Birder, Nakamura, Kiss et al.: "Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1." in: Nature neuroscience, Vol. 5, Issue 9, pp. 856-60, 2002 (PubMed).

Xue, Yu, Trilk et al.: "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants." in: Genomics, Vol. 76, Issue 1-3, pp. 14-20, 2001 (PubMed).

Eisenberg, Gresalfi, Riccio et al.: "Adsorption of monovalent cations to bilayer membranes containing negative phospholipids." in: Biochemistry, Vol. 18, Issue 23, pp. 5213-23, 1980 (PubMed).

Background publications Caterina, Schumacher, Tominaga et al.: "The capsaicin receptor: a heat-activated ion channel in the pain pathway." in: Nature, Vol. 389, Issue 6653, pp. 816-24, 1997 (PubMed).

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