CD9 (CD9) antibody

Details for Product No. ABIN967348
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Antigen
Synonyms Tspan29, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29
Reactivity
Rat (Rattus)
(242), (84), (36), (30), (26), (19), (14), (13), (12), (6), (2), (1), (1)
Host
Mouse
(182), (70), (51)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(41), (40), (24), (9), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
(228), (126), (50), (48), (47), (44), (33), (30), (23), (19), (13), (10), (3), (2), (2), (1), (1)
Pubmed 6 references available
Quantity 0.1 mg
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Catalog No. ABIN967348
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Clone RPM-7
Isotype IgG3, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Sodium azide is a reversible inhibitor of oxidative metabolism, therefore, antibody preparations containing this preservative agent must not be used in cell cultures nor injected into animals. Sodium azide may be removed by washing stained cells or plate-bound antibody or dialyzing soluble antibody in sodium azide-free buffer. Since endotoxin may also affect the results of functional studies, we recommend the NA/LE (No Azide/Low Endotoxin) antibody format, if available, for in vitro and in vivo use.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD9
Background The RPM.7 antibody reacts with CD9, a 26-kDa member of the transmembrane 4 superfamily. Rat CD9 mRNA is detected in many adult tissues, including neural and hematopoietic tissue. Using RPM.7 mAb in flow cytometric analysis of rat hematopoietic tissues, CD9 is found on platelets, peripheral B- and T-lymphocyte subsets, and leukocyte subpopulations in the bone marrow. In humans, CD9 has been found to be associated with integrins and other cell-surface receptors, and it is suggested to play a role in signal transduction and possibly in regulating cellular adhesive properties. In mice, CD9 has been demonstrated to participate in T-cell costimulation and induction of apoptosis.
Research Area Embryogenesis, Embryonic stem cells, Reproduction, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
General Wright, Tomlinson: "The ins and outs of the transmembrane 4 superfamily." in: Immunology today, Vol. 15, Issue 12, pp. 588-94, 1995 (PubMed).

Kaprielian, Cho, Hadjiargyrou et al.: "CD9, a major platelet cell surface glycoprotein, is a ROCA antigen and is expressed in the nervous system." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 2, pp. 562-73, 1995 (PubMed).

Jennings, Crossno, Fox et al.: "Platelet p24/CD9, a member of the tetraspanin family of proteins." in: Annals of the New York Academy of Sciences, Vol. 714, pp. 175-84, 1994 (PubMed).

Park, Yashiro, Tai et al.: "Differential involvement of a Fas-CPP32-like protease pathway in apoptosis of TCR/CD9-costimulated, naive T cells and TCR-restimulated, activated T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 5790-6, 1998 (PubMed).

Terada, Baracskay, Kinter et al.: "The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2." in: Glia, Vol. 40, Issue 3, pp. 350-9, 2002 (PubMed).

Claas, Wahl, Orlicky et al.: "The tetraspanin D6.1A and its molecular partners on rat carcinoma cells." in: The Biochemical journal, Vol. 389, Issue Pt 1, pp. 99-110, 2005 (PubMed).

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