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P-Glycoprotein antibody

Details for Product No. ABIN967562
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Antigen
Synonyms Abcb1, Mdr1a, MDR1, ABCB1, ABCB4, CMDR1, xemdr
Reactivity
Human
(6), (2), (2), (2), (1)
Host
Mouse
(4), (3)
Clonality (Clone)
Monoclonal ()
Application
Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
(5), (4), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN967562
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Clone 17F9
Isotype IgG2b, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Background Reacts with a 170-180 kDa transmembrane glycoprotein (P-glycoprotein), a product of the multidrug resistance-1 (MDR1) gene. This glycoprotein is expressed on MDR positive cells and has been reported to be expressed on many normal tissues, such as adrenal glands and endothelium, in the brain and skin. P-glycoprotein is known to impart drug resistance to cells by pumping many anti-cancer drugs out of the cytoplasm. 17F9 antibody binds to the surface of the viable, unfixed MDR+ cell line, PMG-Y (please inquire), and is able to partially block the binding of UIC2 antibody (another MDR-specific monoclonal antibody). Immunoprecipitation application is reported, but not routinely tested in house.
Synonyms: MDR
Application Notes Positive control cells are available through special order
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
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anti-P-Glycoprotein antibody Profile of P-glycoprotein (MDR) expressed on PMG-Y cell line analyzed on a FACScan (BDIS, San Jose, CA)
Product cited in: Bénard, Bourhis, Riou: "Clinical significance of multiple drug resistance in human cancers." in: Anticancer research, Vol. 10, Issue 5A, pp. 1297-302, 1990 (PubMed).

Goldstein, Galski, Fojo et al.: "Expression of a multidrug resistance gene in human cancers." in: Journal of the National Cancer Institute, Vol. 81, Issue 2, pp. 116-24, 1989 (PubMed).

Shi, Wrin, Reeder et al.: "High-affinity monoclonal antibodies against P-glycoprotein." in: Clinical immunology and immunopathology, Vol. 76, Issue 1 Pt 1, pp. 44-51, 1995 (PubMed).

Hosts (4), (3)
Reactivities (6), (2), (2), (2), (1)
Applications (5), (4), (3), (2), (1), (1), (1)
Epitopes (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN967562
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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