Forkhead Box A2 (FOXA2) antibody

Details for Product No. ABIN967680
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Antigen
Synonyms
hnf3b, tcf3b, hnf3beta, hnf3-beta, FOXA2, HNF3B, TCF3B, HNF-3B, ax, axl, fkd1, ik:tdsubc_2g8, tdsubc_2g8, wu:fe05g04, xx:tdsubc_2g8, FoxA2-A, FoxA2a, xFD-3, xbeta-1, HNF-3b, HNF3-beta, HNF3beta, Hnf-3 ... show more
hnf3b, tcf3b, hnf3beta, hnf3-beta, FOXA2, HNF3B, TCF3B, HNF-3B, ax, axl, fkd1, ik:tdsubc_2g8, tdsubc_2g8, wu:fe05g04, xx:tdsubc_2g8, FoxA2-A, FoxA2a, xFD-3, xbeta-1, HNF-3b, HNF3-beta, HNF3beta, Hnf-3b, Hnf3b, Tcf-3b, Tcf3b, HNF-3BETA show less
Reactivity
Human
(152), (26), (24), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(81), (54), (21)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (7), (7), (7), (6), (6), (1), (1), (1), (1), (1), (1), (1), (1)
Application
BioImaging (BI), Intracellular Flow Cytometry (ICFC), Western Blotting (WB)
(144), (86), (69), (47), (31), (15), (13), (10), (10), (9), (6), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
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Immunogen Human FoxA2 Peptide
Clone N17-280
Isotype IgG1, kappa
Cross-Reactivity (Details) Predicted: Mouse
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Sodium azide is a reversible inhibitor of oxidative metabolism, therefore, antibody preparations containing this preservative agent must not be used in cell cultures nor injected into animals. Sodium azide may be removed by washing stained cells or plate-bound antibody or dialyzing soluble antibody in sodium azide-free buffer. Since endotoxin may also affect the results of functional studies, we recommend the NA/LE (No Azide/Low Endotoxin) antibody format, if available, for in vitro and in vivo use.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. Triton is a trademark of the Dow Chemical Company.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name FOXA2 (FOXA2 Antibody Abstract)
Background FoxA2, forkhead box A2, is a member of the forkhead class of DNA-binding proteins that regulates gene expression in the liver, pancreatic islets, adipocytes and some neural cells. This hepatocyte nuclear factor is a transcriptional activator for liver-specific genes such as alpha fetoprotein, albumin, tyrosine aminotransferase and transthyretin. FoxA2 is expressed in embryonic endoderm, the germ layer that gives rise to the digestive system, and contributes to the specification of the pancreas and the regulation of glucose homoeostasis. FoxA2 also has roles in neural development. Specifically, FoxA2 cooperates with related FoxA1 in the specification and differentiation of midbrain dopaminergic neurons in a dosage-dependent manner.
Synonyms: Forkhead box A2, HNF3B, HNF-3B, HNF-3beta, hepatocyte nuclear factor 3beta
Molecular Weight 48 kDa
Research Area Lineage Markers, Transcription Factors
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Forkhead Box A2 (FOXA2) antibody Western blot analysis of FoxA2 in definitive endoderm derived from human embryonic st...
anti-Forkhead Box A2 (FOXA2) antibody (2) Immunofluorescent staining of FoxA2 in definitive endoderm derived from human embryon...
Product cited in: Lin, Metzakopian, Mavromatakis et al.: "Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development." in: Developmental biology, Vol. 333, Issue 2, pp. 386-96, 2009 (PubMed).

Burtscher, Lickert: "Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo." in: Development (Cambridge, England), Vol. 136, Issue 6, pp. 1029-38, 2009 (PubMed).

DAmour, Agulnick, Eliazer et al.: "Efficient differentiation of human embryonic stem cells to definitive endoderm." in: Nature biotechnology, Vol. 23, Issue 12, pp. 1534-41, 2005 (PubMed).

Thomson, Itskovitz-Eldor, Shapiro et al.: "Embryonic stem cell lines derived from human blastocysts." in: Science (New York, N.Y.), Vol. 282, Issue 5391, pp. 1145-7, 1998 (PubMed).

Monaghan, Kaestner, Grau et al.: "Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm." in: Development (Cambridge, England), Vol. 119, Issue 3, pp. 567-78, 1994 (PubMed).

Clevidence, Overdier, Tao et al.: "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 9, pp. 3948-52, 1993 (PubMed).

Lai, Prezioso, Tao et al.: "Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head." in: Genes & development, Vol. 5, Issue 3, pp. 416-27, 1991 (PubMed).

Validation Images
Catalog No. ABIN967680
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