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YES (AA 10-193) antibody

Details for Product No. ABIN967927
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Antigen
Synonyms HsT441, P61-YES, Yes, c-yes, p61-Yes
Epitope
AA 10-193
(1), (1)
Reactivity
Human
(2), (1)
Host
Mouse
(2)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
(2), (2)
Pubmed 5 references available
Quantity 150 µg
Options
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Catalog No. ABIN967927
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Immunogen Human Yes
Clone 1
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Chicken, Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Background Yes is a member of the Src family of tyrosine kinases. The cellular gene was initially identified as a homologue of v-yes, the oncogene of avian sarcoma virus Y73. At least nine different Src family members have been identified. yes, fyn, and Src are widely expressed in a variety of cell types, while the remaining members are primarily expressed in hematopoietic cells. Members of this family have several common features: they have unique N-terminal domains, they attach to cellular membranes through a myristylated N-terminus and they have homologus SH2, SH3, and catalytic domains. The common expression patterns of Yes, fyn, and Src suggest some overlapping functions. All three of these kinases can physically associate with a number of cell-surface molecules which appear to increase their catalytic activity.
Molecular Weight 62 kDa
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-YES (AA 10-193) antibody Western blot analysis of Yes on a A431 cell lysate (Human epithelial carcinoma, ATCC CRL-1555). Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the Mouse Anti-Yes antibody.
anti-YES (AA 10-193) antibody (2) Immunohistochemical staining on a rabbit brain tissue section with the Mouse Anti-Yes antibody.
anti-YES (AA 10-193) antibody (3) anti-YES (AA 10-193) antibody (Image 3)
Product cited in: Sukegawa, Semba, Yamanashi et al.: "Characterization of cDNA clones for the human c-yes gene." in: Molecular and cellular biology, Vol. 7, Issue 1, pp. 41-7, 1987 (PubMed).

Park, Cartwright: "Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells." in: Molecular and cellular biology, Vol. 15, Issue 5, pp. 2374-82, 1995 (PubMed).

Encinas, Tansey, Tsui-Pierchala et al.: "c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 5, pp. 1464-72, 2001 (PubMed).

Lee, Bonnah, Higashi et al.: "CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae." in: The Journal of cell biology, Vol. 156, Issue 6, pp. 951-7, 2002 (PubMed).

Chen, Lu, Goodenough et al.: "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells." in: Molecular biology of the cell, Vol. 13, Issue 4, pp. 1227-37, 2002 (PubMed).

Validation Images
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