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Heat Shock Protein 90 (HSP90) (AA 586-732) antibody

Details for Product No. ABIN967957
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Antigen
Synonyms
git10, swo1, HSP90, htpG, SCBAC25F8.08, 23.m06066, 17.m07646, HSP90-1, 143198_at, 83, 83K HSP, DMHSP82, E(sev)3A, E(sina)2, HSP82, HSP83, ORF1, Su(Raf)3A, anon-EST:Liang-2.53, anon-WO0068693, anon-WO0 ... show more
git10, swo1, HSP90, htpG, SCBAC25F8.08, 23.m06066, 17.m07646, HSP90-1, 143198_at, 83, 83K HSP, DMHSP82, E(sev)3A, E(sina)2, HSP82, HSP83, ORF1, Su(Raf)3A, anon-EST:Liang-2.53, anon-WO0068693, anon-WO0140519.209, clone 2.53, en(lz)3C/4C, hsp84, l(3)j5C2, ms(3)08445, stc, DmelCG1242, CG1242, 86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4, Hsp86, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2, hsp86, hsp89, hsp90, hsp90a, hspc1, hspca, hspn, lap2, D6S182, HSP84, HSP90B, HSPC2, HSPCB show less
Epitope
AA 586-732
(17), (9), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(140), (55), (53), (30), (23), (12), (7), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(110), (50), (6), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
(145), (88), (82), (71), (38), (31), (25), (9), (4), (2), (2)
Pubmed 6 references available
Quantity 50 µg
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Catalog No. ABIN967957
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Immunogen Human Hsp90
Clone 6D12
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Hsp90
Background The 90 kDa heat shock protein (Hsp90), a highly conserved stress-induced protein, is abundantly expressed in most tissues under nonstress conditions and is required for eukaryotic cell viability. Hsp90 interacts with a number of signaling molecules, other heat shock proteins, and cytoskeletal proteins. However, the function of Hsp90 in these complexes remains unclear. It is thought that Hsp90 plays a common role in a number of diverse signaling systems due to its physical association with v-Src family tyrosine kinases, steroid hormone receptors, the Raf serine/threonine kinase, the basic-helix-loop-helix dioxin receptor, and the betagamma subunits of G proteins.
Synonyms: Heat Shock Protein-90
Molecular Weight 90 kDa
Research Area Cancer, Heat Shock Proteins
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Heat Shock Protein 90 (HSP90) (AA 586-732) antibody Western blot analysis of Hsp90 on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-Hsp90 antibody.
anti-Heat Shock Protein 90 (HSP90) (AA 586-732) antibody (2) Immunofluorescence staining of WI-38 cells (Human lung fibroblasts, ATCC CCL-75).
Product cited in: Rebbe, Ware, Bertina et al.: "Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family." in: Gene, Vol. 53, Issue 2-3, pp. 235-45, 1987 (PubMed).

Pritchard, Ackerman, Gross et al.: "Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase." in: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 17621-4, 2001 (PubMed).

Brouet, Sonveaux, Dessy et al.: "Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 32663-9, 2001 (PubMed).

Miyamoto, Nakayama, Imaki et al.: "Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta." in: Nature, Vol. 416, Issue 6883, pp. 865-9, 2002 (PubMed).

Murata, Sato, Hori et al.: "Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 44085-92, 2002 (PubMed).

Murata, Suzuki, Yamawaki et al.: "Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum." in: European journal of pharmacology, Vol. 515, Issue 1-3, pp. 134-41, 2005 (PubMed).

Validation Images
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