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HSP90 antibody (Heat Shock Protein 90) (AA 586-732)

Details for Product anti-HSP90 Antibody No. ABIN967957, Supplier: Login to see
Antigen
  • git10
  • swo1
  • HSP90
  • htpG
  • SCBAC25F8.08
  • 23.m06066
  • 17.m07646
  • HSP90-1
  • 143198_at
  • 83
  • 83K HSP
  • DMHSP82
  • E(sev)3A
  • E(sina)2
  • HSP82
  • HSP83
  • ORF1
  • Su(Raf)3A
  • anon-EST:Liang-2.53
  • anon-WO0068693
  • anon-WO0140519.209
  • clone 2.53
  • en(lz)3C/4C
  • hsp84
  • l(3)j5C2
  • ms(3)08445
  • stc
  • DmelCG1242
  • CG1242
  • 86kDa
  • 89kDa
  • AL024080
  • AL024147
  • Hsp86-1
  • Hsp89
  • Hsp90
  • Hspca
  • hsp4
  • Hsp86
  • EL52
  • HSP86
  • HSP89A
  • HSP90A
  • HSP90N
  • HSPC1
  • HSPCA
  • HSPCAL1
  • HSPCAL4
  • HSPN
  • LAP2
  • hsp86
  • hsp89
  • hsp90
  • hsp90a
  • hspc1
  • hspca
  • hspn
  • lap2
  • D6S182
  • HSP84
  • HSP90B
  • HSPC2
  • HSPCB
Epitope
AA 586-732
51
16
11
8
6
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
268
164
157
93
68
36
22
21
21
19
19
18
18
18
9
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Host
Mouse
193
110
7
1
Clonality (Clone)
Monoclonal ()
Conjugate
This HSP90 antibody is un-conjugated
11
11
9
9
9
9
9
9
9
9
9
9
9
9
9
9
8
2
2
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
275
192
178
166
124
117
37
6
2
2
2
Supplier
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Immunogen Human Hsp90 aa. 586-732
Clone 68-Hsp90
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Hsp90 (HSP90 Antibody Abstract)
Background The 90 kDa heat shock protein (Hsp90), a highly conserved stress-induced protein, is abundantly expressed in most tissues under nonstress conditions and is required for eukaryotic cell viability. Hsp90 interacts with a number of signaling molecules, other heat shock proteins, and cytoskeletal proteins. However, the function of Hsp90 in these complexes remains unclear. It is thought that Hsp90 plays a common role in a number of diverse signaling systems due to its physical association with v-Src family tyrosine kinases, steroid hormone receptors, the Raf serine/threonine kinase, the basic-helix-loop-helix dioxin receptor, and the betagamma subunits of G proteins.
Synonyms: Heat Shock Protein-90
Molecular Weight 90 kDa
Research Area Cancer, Heat Shock Proteins
Pathways
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-HSP90 antibody (Heat Shock Protein 90) (AA 586-732) (ABIN967957) Western blot analysis of Hsp90 on a HeLa cell lysate (Human cervical epitheloid carci...
Immunofluorescence (IF) image for anti-HSP90 antibody (Heat Shock Protein 90) (AA 586-732) (ABIN967957) Immunofluorescence staining of WI-38 cells (Human lung fibroblasts, ATCC CCL-75).
Product cited in: Murata, Suzuki, Yamawaki et al.: "Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum." in: European journal of pharmacology, Vol. 515, Issue 1-3, pp. 134-41, 2005 (PubMed).

Murata, Sato, Hori et al.: "Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 44085-92, 2002 (PubMed).

Miyamoto, Nakayama, Imaki et al.: "Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta." in: Nature, Vol. 416, Issue 6883, pp. 865-9, 2002 (PubMed).

Brouet, Sonveaux, Dessy et al.: "Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 32663-9, 2001 (PubMed).

Pritchard, Ackerman, Gross et al.: "Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase." in: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 17621-4, 2001 (PubMed).

Rebbe, Ware, Bertina et al.: "Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family." in: Gene, Vol. 53, Issue 2-3, pp. 235-45, 1987 (PubMed).