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Details for Product No. ABIN968028

CaM Kinase Kinase (AA 341-504) antibody

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Antigen
Epitope
AA 341-504
Reactivity
Rat (Rattus)
Host
Mouse
Clonality (Clone) Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF)
Pubmed 5 references available
Catalog no. ABIN968028
Quantity 50 µg
Price
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Immunogen Rat CaM Kinase Kinase
Clone 6
Isotype IgG2a
Cross-Reactivity Human, Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Background Ca2+/Calmodulin (CaM)-dependent kinases are multifunctional kinases involved in a myriad of cellular functions such as neurotransmitter synthesis, long-term potentiation, and formation of spatial learning. A 68kDa CaM Kinase Kinase with homology to the Ca2+/CaM-dependent kinases, phosphorylates and activates Ca2+/CaM-dependent protein kinases I and IV, but not type II. This phosphorylation occurs on Ser/Thr residues and is Ca2+ and CaM dependent. CaM Kinase Kinase is abundant in brain tissue, and is thought to be an upstream regulator in the Ca2+/CaM-dependent neural processes. This antibody is routinely tested by western blot analysis.
Molecular Weight 68 kDa
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Tokumitsu, Enslen, Soderling: "Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase." in: The Journal of biological chemistry, Vol. 270, Issue 33, pp. 19320-4, 1995 (PubMed).

Edelman, Mitchelhill, Selbert et al.: "Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence." in: The Journal of biological chemistry, Vol. 271, Issue 18, pp. 10806-10, 1996 (PubMed).

Wu, Means: "Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix." in: The Journal of biological chemistry, Vol. 275, Issue 11, pp. 7994-9, 2000 (PubMed).

Wayman, Walters, Kolibaba et al.: "CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner." in: The Journal of cell biology, Vol. 151, Issue 4, pp. 811-24, 2000 (PubMed).

Egea, Espinet, Soler et al.: "Neuronal survival induced by neurotrophins requires calmodulin." in: The Journal of cell biology, Vol. 154, Issue 3, pp. 585-97, 2001 (PubMed).

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