Dynein, Light Chain, LC8-Type 1 (DYNLL1) (AA 1-89) antibody

Details for Product No. ABIN968140
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Antigen
Synonyms
lc8, dlc1, dlc8, lc8a, dncl1, dnclc1, dynll1a, MGC68763, pin, hdlc1, MGC89636, LC8, rhogap7, ARHGAP7, Dlc-1, STARD12, DLC-1, StARD12, A730069N07Rik, Arhgap7, HP, dlc-1, RhoGAP, DLC1, F56, Dlc8, Dnclc1 ... show more
lc8, dlc1, dlc8, lc8a, dncl1, dnclc1, dynll1a, MGC68763, pin, hdlc1, MGC89636, LC8, rhogap7, ARHGAP7, Dlc-1, STARD12, DLC-1, StARD12, A730069N07Rik, Arhgap7, HP, dlc-1, RhoGAP, DLC1, F56, Dlc8, Dnclc1, Pin, 8kDLC, DLC8, DNCL1, DNCLC1, LC8a, PIN, dynll1, dynll1b, DYNLL1, CDLC2, dynll2, wu:fd56c09, zgc:73406 show less
Epitope
AA 1-89
(11), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(52), (28), (24), (15), (12), (4), (3), (2), (2), (2), (2), (1)
Host
Mouse
(43), (6), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(38), (15), (14), (10), (9), (7), (6), (5), (3), (1)
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN968140
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Immunogen Rat PIN
Clone 4
Isotype IgG1
Cross-Reactivity Human
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name PIN
Background PIN (protein inhibitor of nNOS) is a small protein of 89 amino acids initially described as a light chain subunit of dynein and as an inhibitor of the neuronal nitric oxide synthase isoform (nNOS). In vitro, PIN has been reported to bind to a unique nNOS domain encompassing amino acids 163-245. PIN inhibits nNOS activity and blocks the formation of the active nNOS dimer. Although ubiquitously expressed, PIN levels are reportedly highest in brain and testis. Immunolocalization studies in Drosophila melanogaster detected a cytoplasmic distribution of PIN. Partial-loss-of-function of PIN resulted in morphologic and developmental changes in the bristles, wings, and female sterility of D. melanogaster. Deletion of PIN resulted in lethality with the characteristic morphology of apoptotic cells. This antibody is routinely tested by western blot analysis.
Synonyms: Protein Inhibitor of nNOS
Molecular Weight 10 kDa
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Dynein, Light Chain, LC8-Type 1 (DYNLL1) (AA 1-89) antibody Immunofluorescence staining of rat neurons.
anti-Dynein, Light Chain, LC8-Type 1 (DYNLL1) (AA 1-89) antibody (2) Western blot analysis of PIN on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- PIN antibody.
Product cited in: Dick, Ray, Salz et al.: "Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster." in: Molecular and cellular biology, Vol. 16, Issue 5, pp. 1966-77, 1996 (PubMed).

Jaffrey, Snyder: "PIN: an associated protein inhibitor of neuronal nitric oxide synthase." in: Science (New York, N.Y.), Vol. 274, Issue 5288, pp. 774-7, 1996 (PubMed).

Validation Images
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