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Details for Product No. ABIN968150

RON alpha (AA 40-224) antibody

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Antigen
Epitope
AA 40-224
Reactivity
Human
Host
Mouse
Clonality (Clone) Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN968150
Quantity 50 µg
Price
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Immunogen Human RON alpha
Clone OPG-01
Isotype IgG2b
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Background RON (Recepteur d'Origine Nantaise) is a tyrosine kinase receptor for MSP (Macrophage Stimulating Protein) that belongs to the hepatocyte growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon maturation into a 150 kDa beta-subunit with the kinase activity and a 40 kDa alpha-chain. Both chains are linked by disulfide bonds and the proper arrangement of the alpha and beta heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON, triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP. Therefore, autophosphorylation at Y1330 and Y1337 is required for RON's biological activity. PLCgamma, Shc, Grb2, p61, and p65 associate with RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney, and testis.
Synonyms: Recepteur d'Origine Nantaise
Molecular Weight 40 kDa
Comment

Related Products: ABIN968619, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Wang, Ronsin, Gesnel et al.: "Identification of the ron gene product as the receptor for the human macrophage stimulating protein." in: Science (New York, N.Y.), Vol. 266, Issue 5182, pp. 117-9, 1994 (PubMed).

Gaudino, Follenzi, Naldini et al.: "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP." in: The EMBO journal, Vol. 13, Issue 15, pp. 3524-32, 1994 (PubMed).

Ronsin, Muscatelli, Mattei et al.: "A novel putative receptor protein tyrosine kinase of the met family." in: Oncogene, Vol. 8, Issue 5, pp. 1195-202, 1993 (PubMed).

Peace, Hughes, Degen et al.: "Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis." in: Oncogene, Vol. 20, Issue 43, pp. 6142-51, 2001 (PubMed).

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