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XIAP antibody (X-Linked Inhibitor of Apoptosis) (AA 268-426)

Details for Product anti-XIAP Antibody No. ABIN968163, Supplier: Login to see New
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Synonyms BIRC4, api3, birc4, ilp1, miha, xlp2, xxiap, API3, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, 1110015C02Rik, Aipa, Api3, Birc4, IAP3, ILP-1, mXIAP, riap3
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AA 268-426
(26), (22), (13), (8), (7), (6), (5), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Frog, Human, Mouse (Murine), Rat (Rattus)
(159), (55), (36), (6), (4), (4), (2), (1)
(142), (22), (1)
Clonality (Clone)
Monoclonal ()
This XIAP antibody is un-conjugated
(6), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(137), (57), (56), (34), (22), (18), (11), (11), (11), (7), (3), (2), (1), (1), (1)
Pubmed 5 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Human hILP aa. 268-426
Clone 48-hILP-XIAP
Isotype IgG1
Cross-Reactivity Rat (Rattus), Mouse (Murine), Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name hILP (XIAP Antibody Abstract)
Background Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms. Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival. Therefore, many viruses encode proteins that protect the cell from apoptosis. hILP (human IAP-like protein) is a human homologue of the viral IAP (Inhibitor of Apoptosis Protein). hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain. hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1beta converting enzyme) expression. This product is sold under license from Aegera Therapeutics, Inc. This antibody is routinely tested by western blot analysis.
Synonyms: hILP
Molecular Weight 57 kDa
Pathways Apoptosis, Caspase Cascade in Apoptosis

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-XIAP antibody (X-Linked Inhibitor of Apoptosis) (AA 268-426) (ABIN968163) Western blot analysis of hILP/XIAP on Jurkat lysate. Lane 1: 1:4000, lane 2: 1:8000, ...
Immunofluorescence (IF) image for anti-XIAP antibody (X-Linked Inhibitor of Apoptosis) (AA 268-426) (ABIN968163) Immunofluorescent staining of Rabbit Liver tissue with anti-XIAP
Product cited in: Deng, Lin, Wu: "TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO." in: Genes & development, Vol. 16, Issue 1, pp. 33-45, 2002 (PubMed).

Martins, Iaccarino, Tenev et al.: "The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 439-44, 2002 (PubMed).

Fulda, Meyer, Debatin: "Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression." in: Cancer research, Vol. 60, Issue 14, pp. 3947-56, 2000 (PubMed).

Tamm, Kornblau, Segall et al.: "Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1796-803, 2000 (PubMed).

Duckett, Nava, Gedrich et al.: "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2685-94, 1996 (PubMed).

Catalog No. ABIN968163
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