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Details for Product No. ABIN968174

Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 353-486) antibody

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CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, DXPri1, DXRib1, LIN-2, Pals3, mLin-2, wu:fb70g06, CAKI, CG13412, CG13413, CG6703, CMG/CASK, Caki, CamGUK, CamguK, Camguk, Cask, Cmg, DLin-2, Dme ... show more
»Alternatives AA 353-486
»Alternatives Rat (Rattus)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 5 references available
Catalog no. ABIN968174
Quantity 50 µg
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Immunogen Rat CASK
Clone 7
Isotype IgG1
Cross-Reactivity Mouse (Murine), Human, Dog (Canine), Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name CASK
Background CASK is a recently identified cytosolic protein kinase with homology to the Ca2+/CaM-dependent kinases and the synaptic associated proteins SAPs/PSDs. Like the SAPs, CASK contains a PDZ domain, an SH3 region, and a guanylate kinase domain. However, unlike the rest of the PDZ protein family, the amino terminus of CASK has significant homology with the Ca2+/Calmodulin-dependent kinases. Although widely expressed, CASK is highly enriched in the synaptic plasma membrane where it associates with neurexins, the neuronal cell surface proteins. Neurexins are a complex family of surface proteins that act as receptors for a number of venoms and toxins and regulate the clustering of several ion channels at the synapse. In addition, neurexins bind heterotypically to neuroligins, therefore adjoining different cell types. Neuroligins bind intracellularly to PSD95 and related proteins, whereas neurexins bind to CASK through their C-terminal region and at CASK's PDZ domain. The interaction of neurexins and CASK at the outside of the cell may modulate CASK's activity and trigger an intracellular signaling cascade.
Molecular Weight 120 kDa
Research Area Neurology

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Hata, Butz, Südhof: "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 8, pp. 2488-94, 1996 (PubMed).

Irie, Hata, Takeuchi et al.: "Binding of neuroligins to PSD-95." in: Science (New York, N.Y.), Vol. 277, Issue 5331, pp. 1511-5, 1997 (PubMed).

Borg, Lõpez-Figueroa, de Taddèo-Borg et al.: "Molecular analysis of the X11-mLin-2/CASK complex in brain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 4, pp. 1307-16, 1999 (PubMed).

Biederer, Sudhof: "CASK and protein 4.1 support F-actin nucleation on neurexins." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 47869-76, 2001 (PubMed).

Fallon, Moreau, Croft et al.: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 (PubMed).

Alternatives for antigen "Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK)", type "Antibodies"
Hosts (39), (8)
Reactivities (39), (32), (31), (13), (12), (12), (6), (5), (1), (1), (1)
Applications (38), (14), (12), (11), (10), (5), (3), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (5), (2), (2), (2), (2)