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Utrophin (UTRN) (AA 768-874) antibody

Details for Product No. ABIN968237
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Antigen
Synonyms drp, dmdl, drp1, DKFZp469A0710, DMDL, DRP, DRP1, AA589569, Dmdl
Epitope
AA 768-874
(2)
Reactivity
Mouse (Murine)
(16), (12), (12), (12), (12), (12), (12)
Host
Mouse
(12), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(10), (3), (3), (3), (2), (1)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN968237
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Immunogen Mouse Utrophin
Clone 55
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Utrophin
Background Utrophin is an autosomal homolog of dystrophin located on chromosome 6q24. Both encode large cytoskeletal proteins that are members of the spectrin superfamily. Spectrin family proteins are located at the cytoplasmic face and link the intracellular cytoskeleton to the extracellular matrix. Utrophin is nearly identical to dystrophin, specifically in the N-terminal actin binding domain and the C-terminus. Dystrophin is expressed primarily in the brain and muscle, while Utrophin is ubiquitously expressed. In skeletal muscle, Utrophin expression varies depending on the the state of differentiation and innervation of muscle fibers. During development, it localizes in the sarcolemma. Following formation of synaptic contacts, Utrophin is found within the postsynaptic membrane domain of the neuromuscular junction. However, its expression is not limited to postsynaptic compartments. Although dystrophin is absent in patients with Duchenne muscular dystrophy (DMD) and mdx (dystrophin deficient) mice, Utrophin is upregulated. The regulation mechanisms underlying Utrophin expression in muscle have yet to be determined.
Molecular Weight 400 kDa
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Utrophin (UTRN) (AA 768-874) antibody Western blot analysis of Utrophin on a mouse neonate lysate. Lane 1: 1: 250, lane 2: 1: 500, lane 3: 1:1000 dilution of the mouse anti-mouse Utrophin antibody.
anti-Utrophin (UTRN) (AA 768-874) antibody (2) anti-Utrophin (UTRN) (AA 768-874) antibody (Image 2)
Product cited in: Tinsley, Blake, Roche et al.: "Primary structure of dystrophin-related protein." in: Nature, Vol. 360, Issue 6404, pp. 591-3, 1993 (PubMed).

Guo, Nichol, Merlie: "Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters." in: FEBS letters, Vol. 398, Issue 2-3, pp. 259-64, 1997 (PubMed).

Deconinck, Rafael, Skinner et al.: "Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy." in: Cell, Vol. 90, Issue 4, pp. 717-27, 1997 (PubMed).

Grady, Teng, Nichol et al.: "Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy." in: Cell, Vol. 90, Issue 4, pp. 729-38, 1997 (PubMed).

Gramolini, Burton, Tinsley et al.: "Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism." in: The Journal of biological chemistry, Vol. 273, Issue 2, pp. 736-43, 1998 (PubMed).

Validation Images
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