CD38 (AA 171-292) antibody

Details for Product No. ABIN968373
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Antigen
Synonyms Cd38-rs1, T10
Epitope
AA 171-292
(20), (16), (6), (5), (2), (2), (2), (1), (1)
Reactivity
Human
(256), (172), (13), (1)
Host
Mouse
(199), (148), (81), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(61), (52), (44), (25), (8), (8), (6), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(341), (84), (84), (77), (55), (54), (40), (23), (20), (14), (7), (5), (5), (4), (2)
Pubmed 3 references available
Quantity 50 μg
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Catalog No. ABIN968373
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Immunogen Human CD38
Clone LPR-02
Isotype IgG1, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Background Lymphocyte trafficking is essential for efficient immune responses in that it allows antigen sensitive lymphocytes to encounter antigen and be recruited to sites of infection. Trafficking involves the passage of lymphocytes across the HEV, a process that is mediated by selectins. CD38 is a single-chain type II transmembrane glycoprotein that is expressed by a variety of immature and activated lymphocytes. It mediates a selectin-like binding to endothelial cells, thus functioning as an adhesion molecule. Human and mouse forms of the protein are highly similar and homologous to the Aplysia californica ADP-ribosyl-cyclase. CD38 catalyzes the synthesis of cyclic ADP-ribose (cADPR), a putative endogenous regulator of calcium release. This is thought to be key to CD38-mediated signal transduction. A possible ligand for CD38 is the Ig superfamily protein CD31. In addition, activation of CD38 with a monoclonal antibody induces leukemic cell proliferation. Thus, CD38 is a cell surface protein that is important for lymphocyte migration and may be involved in the propagation of leukemic cells in AML (acute myelogenous leukemia).
Molecular Weight 46 kDa
Research Area CD Antigens, Surface Receptors of Immune Cells
Comment

Related Products: ABIN967389, ABIN968584

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-CD38 (AA 171-292) antibody Immunofluorescence staining of Human Endothelial cells.
anti-CD38 (AA 171-292) antibody (2) Western blot analysis of CD38 on EB1 lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of CD38.
anti-CD38 (AA 171-292) antibody (3) anti-CD38 (AA 171-292) antibody (Image 3)
Product cited in: Jackson, Bell: "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 7, pp. 2811-5, 1990 (PubMed).

Deaglio, Morra, Mallone et al.: "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 1, pp. 395-402, 1998 (PubMed).

Konopleva, Estrov, Zhao et al.: "Ligation of cell surface CD38 protein with agonistic monoclonal antibody induces a cell growth signal in myeloid leukemia cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 9, pp. 4702-8, 1998 (PubMed).

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