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Ubiquitin Protein Ligase E3A (ube3a) (AA 501-712) antibody

Details for Product No. ABIN968525
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Antigen
Synonyms
ANCR, AS, E6-AP, EPVE6AP, HPVE6A, im:7140733, zgc:92173, 4732496B02, 5830462N02Rik, A130086L21Rik, Hpve6a, mKIAA4216, As, CG6190, Dmel\\CG6190, Dube3a, UBE3A, dUBE3A, das, dube3A, dube3a, UME3A, DDBDR ... show more
ANCR, AS, E6-AP, EPVE6AP, HPVE6A, im:7140733, zgc:92173, 4732496B02, 5830462N02Rik, A130086L21Rik, Hpve6a, mKIAA4216, As, CG6190, Dmel\\CG6190, Dube3a, UBE3A, dUBE3A, das, dube3A, dube3a, UME3A, DDBDRAFT_0188760, DDBDRAFT_0302447, DDB_0188760, DDB_0302447, DKFZp459N106, ube3a, MGC69536 show less
Epitope
AA 501-712
(11), (6), (6), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(63), (22), (16), (14), (12), (12), (3), (2), (1), (1)
Host
Mouse
(54), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(53), (28), (18), (10), (10), (10), (9), (7), (6), (2), (1)
Pubmed 2 references available
Quantity 50 µg
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Catalog No. ABIN968525
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Immunogen Mouse UBE3A
Clone 7H3
Isotype IgG1
Cross-Reactivity Human
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name UBE3A
Background Protein ubiquitination is the end product of a multienzyme cascade that involves sequential thiol-ester bond interactions between ubiquitin and enzymes termed E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin protein ligases. UBE3A (human papilloma virus E6-associated protein, E6-AP) is an E3 ubiquitin protein ligase that is linked to the neurological disorder Angelman syndrome. It mediates the interaction of human papilloma virus types 16 and 18 E6 proteins with p53, which targets p53 to the ubiquitination-proteasome degradation pathway. The C-terminal region of UBE3A contains a hect domain, which is found in many E3 ubiquitin protein ligases, while the central region contains an E6 binding region. UBE3A is expressed in the cytoplasm and nucleus of many tissues. The interaction of UBE3A with the progesterone receptor coactivates transciptional activity of the receptor in the presence of bound hormone. Thus, UBE3A is an essential component of the ubiquitination degradation pathway and the nuclear hormone receptor signal transduction pathways. This antibody is routinely tested by western blot analysis.
Synonyms: Ubiquitin Protein Ligase 3A
Molecular Weight 100 kDa
Research Area Chromatin and Nuclear Signaling, Proteolysis / Ubiquitin
Comment

Related Products: ABIN968584, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Ubiquitin Protein Ligase E3A (ube3a) (AA 501-712) antibody Western blot analysis of UBE3A on a EB-1 cell lysate (Human B lymphoblast, Burkitt's lymphoma, ATCC HTB-60). Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti- UEB3A antibody.
anti-Ubiquitin Protein Ligase E3A (ube3a) (AA 501-712) antibody (2) anti-Ubiquitin Protein Ligase E3A (ube3a) (AA 501-712) antibody (Image 2)
Product cited in: Matsuura, Sutcliffe, Fang et al.: "De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome." in: Nature genetics, Vol. 15, Issue 1, pp. 74-7, 1997 (PubMed).

Nawaz, Lonard, Smith et al.: "The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily." in: Molecular and cellular biology, Vol. 19, Issue 2, pp. 1182-9, 1999 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968525
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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