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Details for Product No. ABIN968567

Kinesin Family Member 3A (KIF3A) (AA 563-671) antibody

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Antigen
Synonyms FLA10, KLP-20, 111-11-71, 111-11-86, AW124694, Kif3, Kifl, Kns3
Epitope
»Alternatives AA 563-671
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968567
Quantity 50 µg
Price
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Immunogen Human KIF3A
Clone MOC-31
Isotype IgG1
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics 1. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name KIF3A
Background The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division. Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein. A family of N-terminal motor domain kinesin proteins includes KIF3A/3B, KRP85/95, and Klp68d/64. These proteins form heterodimeric two-headed motors that interact with kinesin associated protein (KAP). The KIF3A/3B/KAP3 heterotrimeric motor has plus-end directed microtubule sliding activity. This heterotrimeric motor is expressed ubiquitously and is used for anterograde transport of membranous organelles. KIF3A- and KIF3B-deficient mice have defects in the formation of the cilia located in the embryonic node. In addition, KIF3A localizes to the basal body of the connecting cilium axoneme and to vesicles at the pre-synaptic ribbon in photoreceptor cells. Thus, KIF3 motors are involved in microtubule-based formation and movement of cilia and the transport of synaptic vesicles. This antibody is routinely tested by the Western blot analysis.
Molecular Weight 80/85 kDa
Research Area Stem Cells, Cancer, Cytoskeleton
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Hirokawa: "Kinesin and dynein superfamily proteins and the mechanism of organelle transport." in: Science (New York, N.Y.), Vol. 279, Issue 5350, pp. 519-26, 1998 (PubMed).

Muresan, Lyass, Schnapp: "The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 3, pp. 1027-37, 1999 (PubMed).

Marszalek, Ruiz-Lozano, Roberts et al.: "Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 9, pp. 5043-8, 1999 (PubMed).

Alternatives for antigen "Kinesin Family Member 3A (KIF3A)", type "Antibodies"
Hosts (22), (1)
Reactivities (22), (15), (15), (13), (13), (13), (12), (1)
Applications (13), (10), (5), (3), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (2), (1)
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