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Kinesin Family Member 3A (KIF3A) (AA 563-671) antibody

Details for Product No. ABIN968567
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Antigen
Synonyms FLA10, KLP-20, 111-11-71, 111-11-86, AW124694, Kif3, Kifl, Kns3
Epitope
AA 563-671
(8), (7), (1)
Reactivity
Human
(27), (16), (15), (13), (13), (13), (12), (1)
Host
Mouse
(27), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(18), (11), (10), (3), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 50 µg
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Catalog No. ABIN968567
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Immunogen Human KIF3A
Clone MOC-31
Isotype IgG1
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics 1. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name KIF3A
Background The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division. Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein. A family of N-terminal motor domain kinesin proteins includes KIF3A/3B, KRP85/95, and Klp68d/64. These proteins form heterodimeric two-headed motors that interact with kinesin associated protein (KAP). The KIF3A/3B/KAP3 heterotrimeric motor has plus-end directed microtubule sliding activity. This heterotrimeric motor is expressed ubiquitously and is used for anterograde transport of membranous organelles. KIF3A- and KIF3B-deficient mice have defects in the formation of the cilia located in the embryonic node. In addition, KIF3A localizes to the basal body of the connecting cilium axoneme and to vesicles at the pre-synaptic ribbon in photoreceptor cells. Thus, KIF3 motors are involved in microtubule-based formation and movement of cilia and the transport of synaptic vesicles. This antibody is routinely tested by the Western blot analysis.
Molecular Weight 80/85 kDa
Research Area Stem Cells, Cancer, Cytoskeleton
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Kinesin Family Member 3A (KIF3A) (AA 563-671) antibody Western blot analysis of KIF3A on rat brain lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of KIF3A.
anti-Kinesin Family Member 3A (KIF3A) (AA 563-671) antibody (2) Rat Neurons
anti-Kinesin Family Member 3A (KIF3A) (AA 563-671) antibody (3) anti-Kinesin Family Member 3A (KIF3A) (AA 563-671) antibody (Image 3)
Product cited in: Hirokawa: "Kinesin and dynein superfamily proteins and the mechanism of organelle transport." in: Science (New York, N.Y.), Vol. 279, Issue 5350, pp. 519-26, 1998 (PubMed).

Muresan, Lyass, Schnapp: "The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 3, pp. 1027-37, 1999 (PubMed).

Marszalek, Ruiz-Lozano, Roberts et al.: "Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 9, pp. 5043-8, 1999 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968567
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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