Multiple PDZ Domain Protein (MPDZ) (AA 65-247) antibody

Details for Product No. ABIN968588
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms HYC2, MUPP1, AI225843, B930003D11Rik
Epitope
AA 65-247
(1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(17), (13), (13), (12), (12), (1)
Host
Mouse
(18), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(10), (7), (5), (4), (3)
Pubmed 2 references available
Catalog no. ABIN968588
Quantity 50 µg
Price
Contact our Customer Service for availability and price in your country.
Options
Shipping to United States (Change)
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Rat MUPP1
Clone BE10
Isotype IgG1
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name MUPP1
Background The postsynaptic density protein PSD-95 interacts with the cytoplasmic tail of ion channel subunits via a protein-protein motif called the PDZ domain. PSD-95 belongs to a family of PDZ domain-containing proteins that includes SAP97/Dlg, PSD-93/chapsyn-110, and SAP102. These proteins are characterized by three PDZ domains in the N-terminal half and an SH3 and guanylate kinase-like domain in the C-terminal region. They may be involved in the localization and clustering of ion channels and receptors at synaptic sites. Other PDZ domain-containing proteins such as glutamate receptor interacting protein (GRIP), Homer, and multi-PDZ-domain protein (MUPP1) do not contain guanylate kinase-like domains, but have also been implicated in receptor localization. MUPP1 contains thirteen PDZ domains and is expressed in human heart, brain, placenta, liver, skeletal muscle, kidney, and pancreas. In addition, smaller variants of MUPP1 are expressed in heart, liver, kidney, and brain. The C-terminal region of the 5-HT2c receptor interacts with MUPP1, suggesting that MUPP1 may have important protein-protein interactions during G-protein coupled receptor signaling.
Molecular Weight 219 kDa
Comment

Related Products: ABIN967389, ABIN968545

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Multiple PDZ Domain Protein (MPDZ) (AA 65-247) antibody Western blot analysis of MUPP1 on rat brain lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-MUPP1 antibody.
Product cited in: Ullmer, Schmuck, Figge et al.: "Cloning and characterization of MUPP1, a novel PDZ domain protein." in: FEBS letters, Vol. 424, Issue 1-2, pp. 63-8, 1998 (PubMed).

Fallon, Moreau, Croft et al.: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 (PubMed).

Hosts (18), (1)
Reactivities (17), (13), (13), (12), (12), (1)
Applications (10), (7), (5), (4), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (1), (1), (1), (1), (1), (1)
back to top