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Doublecortin antibody (DCX) (AA 211-317)

Details for Product anti-DCX Antibody No. ABIN968637, Supplier: Log in to see
Antigen
  • DCX
  • DBCN
  • DC
  • LISX
  • SCLH
  • XLIS
  • Dbct
  • 18C15.5
Epitope
AA 211-317
17
14
6
5
5
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
112
66
44
9
6
3
3
2
1
1
1
1
Host
Mouse
83
26
24
Clonality (Clone)
Monoclonal ()
Conjugate
This Doublecortin antibody is un-conjugated
5
4
4
4
4
4
2
Application
Immunofluorescence (IF), Western Blotting (WB)
118
74
36
21
12
11
11
3
3
3
2
1
Supplier
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Immunogen Mouse Doublecortin aa. 211-317
Clone 30-Doublecortin
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Doublecortin (DCX Antibody Abstract)
Background The cerebral cortex is composed of multiple layers of neurons of distinct types and functions, which perform in unison to orchestrate cognitive function. The formation of the cortex relies on complex signaling mechanisms, which mediate the migration of newly formed neurons from deep within the brain to the superficial regions. Defects in neuronal migration and disruption of the multi-layered cortex are apparent in conditions such as X-linked lissencephaly (XLIS) and subcortical laminar heterotopia (SCLH) or double cortex (DC) syndrome. Mutations in the doublecortin gene have been linked to these brain disorders. Doublecortin is highly expressed in developing brain, primarily in migrating neurons. It is significantly homologous with the N-terminal region of the product of the KIAA0369 gene, a protein that is also similar to the CaM kinase family in its C-terminal region. Doublecortin has four potential MAP kinase family phosphorylation sites and a putative site for Abl tyrosine phosphorylation. Thus, doublecortin is thought to be an integral component of tyrosine kinase signal transduction pathways that regulate neuronal migration and development of the cerebral cortex.
Molecular Weight 41 kDa
Pathways
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Doublecortin antibody (DCX) (AA 211-317) (ABIN968637) Western blot analysis of Doublecortin on a mouse neonate lysate. Lane 1: 1:250, lane ...
Product cited in: Magavi, Leavitt, Macklis: "Induction of neurogenesis in the neocortex of adult mice." in: Nature, Vol. 405, Issue 6789, pp. 951-5, 2000 (PubMed).

Gleeson, Allen, Fox et al.: "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein." in: Cell, Vol. 92, Issue 1, pp. 63-72, 1998 (PubMed).

des Portes, Pinard, Billuart et al.: "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." in: Cell, Vol. 92, Issue 1, pp. 51-61, 1998 (PubMed).