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Doublecortin (DCX) (AA 211-317) antibody

Antigen

Doublecortin (DCX)
Synonyms DCX, 18C15.5, DC, DBCN, LISX, SCLH, XLIS, Dbct
Binding Site
Alternatives

AA 211-317
Clonality Monoclonal (30)
Host
Alternatives

Mouse
Reactivity
Alternatives

Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunofluorescence (IF)
3 references available
Catalog no. ABIN968637
Quantity 50 µg  (250 µg/ml)
Price Product not available in this region.
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anti-Doublecortin (DCX) (AA 211-317) antibody

Additional Information
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Alternative name Doublecortin
Immunogen Mouse Doublecortin
Format Liquid
Isotype IgG1
Clone 30
Description The cerebral cortex is composed of multiple layers of neurons of distinct types and functions, which perform in unison to orchestrate cognitive function. The formation of the cortex relies on complex signaling mechanisms, which mediate the migration of newly formed neurons from deep within the brain to the superficial regions. Defects in neuronal migration and disruption of the multi-layered cortex are apparent in conditions such as X-linked lissencephaly (XLIS) and subcortical laminar heterotopia (SCLH) or double cortex (DC) syndrome. Mutations in the doublecortin gene have been linked to these brain disorders. Doublecortin is highly expressed in developing brain, primarily in migrating neurons. It is significantly homologous with the N-terminal region of the product of the KIAA0369 gene, a protein that is also similar to the CaM kinase family in its C-terminal region. Doublecortin has four potential MAP kinase family phosphorylation sites and a putative site for Abl tyrosine phosphorylation. Thus, doublecortin is thought to be an integral component of tyrosine kinase signal transduction pathways that regulate neuronal migration and development of the cerebral cortex.
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Molecular Weight 41 kDa
Comments

Related Products: ABIN967389

Application Details
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Concentration 250 µg/ml
Purity Purified
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative 0.09% Sodium azide.
Storage Store undiluted at -20°C.
Restrictions For Research Use only

Publications
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Product des Portes, Pinard, Billuart et al.: "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." in: Cell, Vol. 92, Issue 1, pp. 51-61, 1998 (PubMed).

Gleeson, Allen, Fox et al.: "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein." in: Cell, Vol. 92, Issue 1, pp. 63-72, 1998 (PubMed).

Magavi, Leavitt, Macklis: "Induction of neurogenesis in the neocortex of adult mice." in: Nature, Vol. 405, Issue 6789, pp. 951-5, 2000 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "Doublecortin (DCX)", type "Antibodies"
Hosts Rabbit (71), Mouse (6), Goat (4)
Reactivities Human (77), Mouse (Murine) (54), Rat (Rattus) (51), Cow (Bovine) (40), Chicken (39), Dog (Canine) (38), Horse (Equine) (36), Cat (Feline) (1), Pig (Porcine) (1)
Applications Western Blotting (WB) (44), ELISA (38), Immunofluorescence (IF) (35), Immunohistochemistry (IHC) (11), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Flow Cytometry (FACS) (4), Immunoprecipitation (IP) (3), Dot Blot (Dot) (2), Immunoelectron Microscopy (IEM) (2), Dot Blot (DB) (1), Immunocytochemistry (ICC) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1)
Conjugates Biotin (3), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2)
Epitopes C-Term (20), pSer297 (18), Internal Region (3), pSer128 (3), pSer378 (3), AA 232-242 (2), AA 362-411 (2), Ser128 (2), pSer376 (1)