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Ataxin 1 antibody (ATXN1)

Details for Product anti-ATXN1 Antibody No. ABIN968970, Supplier: Login to see New
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(190), (102), (76), (5), (3), (3), (2), (1), (1), (1)
(104), (86), (10), (3)
Clonality (Clone)
Monoclonal ()
This Ataxin 1 antibody is un-conjugated
(10), (9), (7), (6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
(148), (64), (58), (52), (48), (37), (24), (16), (9), (3), (3), (2), (1)
Pubmed 1 reference available
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Quantity 100 μL
Shipping to United States ( )
Immunogen Purified recombinant fragment of human ATXN1 expressed in E. coli.
Clone 2F5
Isotype IgG1
Purification Ascites
Alternative Name ATXN1 (ATXN1 Antibody Abstract)
Background Synonyms:
ATX1, SCA1, D6S504E, ATXN1
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele. At least two transcript variants encoding the same protein have been found for this gene. Tissue specificity: Widely expressed throughout the body.
Molecular Weight 87 kDa
Gene ID 6310
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Flow Cytometry (FACS) image for anti-Ataxin 1 antibody (ATXN1) (ABIN968970) Figure 1: Flow cytometric analysis of Jurkat cells using ATXN1 mouse mAb (green) and ...
Immunocytochemistry (ICC) image for anti-Ataxin 1 antibody (ATXN1) (ABIN968970) Figure 2: Immunofluorescence analysis of NTERA-2 cells using ATXN1 mouse mAb (green) ...
Immunohistochemistry (IHC) image for anti-Ataxin 1 antibody (ATXN1) (ABIN968970) Figure 3: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues (l...
Western Blotting (WB) image for anti-Ataxin 1 antibody (ATXN1) (ABIN968970) Figure 4: Western blot analysis using ATXN1 mAb against HEK293 (1) and ATXN1 (AA: 645...
Product cited in: Lim, Crespo-Barreto, Jafar-Nejad et al.: "Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1." in: Nature, Vol. 452, Issue 7188, pp. 713-8, 2008 (PubMed).

Catalog No. ABIN968970

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