Bone Morphogenetic Protein 4 (BMP4) antibody

Antigen: Bone Morphogenetic Protein 4 (BMP4)

Synonyms: ZYME, BMP2B, OFC11, BMP2B1, MCOPS6, Bmp-4, Bmp2b, Bmp2b1, Bmp2b-1, BOMPR4A, bmp-4, zbmp-4, MGC100779, zgc:100779, BMP4, BMP-4, xbmp4, XBMP-4, Bmp4, MGC127497, zyme, bmp2b, bmp2b1, bmp4

Clonality: Monoclonal (10F4B4)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN968986

Additional Information

Alternative name: BMP4

Gene ID: 652

Immunogen: Purified recombinant fragment of human BMP4 expressed in E. Coli.

Format: Liquid

Isotype: IgG1

Clone: 10F4B4

Description: The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors.BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix.
Synonyms: ZYME, BMP2B, OFC11, BMP2B1, MCOPS6, BMP4

Molecular Weight: 64kDa

Application Details

Application Notes: Western Blotting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Purification: Ascites

Buffer: Ascitic fluid containing 0.03% sodium azide.

Preservative: 0.03% sodium azide

Storage: Store at 4℃, for long term storage, store at -20℃.

Research Area: Organogenesis, Growth Factors, Angiogenesis, Signaling

Restrictions: For Research Use only

Publications

Product: Oida, Iimura, Maruoka et al.: "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 5, Issue 5, pp. 273-5, 1995 (PubMed).

Solmesky, Abekasis, Bulvik et al.: "Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium." in: Stem cells and development, Vol. 18, Issue 9, pp. 1283-92, 2009 (PubMed).