Fatty Acid Binding Protein 4, Adipocyte (FABP4) antibody

Antigen: Fatty Acid Binding Protein 4, Adipocyte (FABP4)

Synonyms: LOC100223994, FABP4, FABP, AFABP, A-FABP, AP2, fabp11, zgc:103587, MGC84940, fabp4, aP2

Clonality: Monoclonal (9B8D)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN969126

Additional Information

Alternative name: FABP4

Gene ID: 2167

Immunogen: Purified recombinant fragment of FABP4 expressed in E. Coli.

Format: Liquid

Isotype: IgG1

Clone: 9B8D

Description: Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long chain fatty acids, their coenzymes and other hydrophobic ligands and small molecules in the cytoplasm. It is thought that the role of these proteins includes fatty acid uptake, intracellular lipid transport and metabolism. FABP4 encodes the fatty acid binding protein found in adipocytes. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders.
Synonyms: aP2, A-FABP, FABP4

Molecular Weight: 14kDa

Application Details

Application Notes: Western Blotting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Purification: Ascites

Buffer: Ascitic fluid containing 0.03% sodium azide.

Preservative: 0.03% sodium azide

Storage: Store at 4℃, for long term storage, store at -20℃.

Research Area: Cell Cycle

Restrictions: For Research Use only

Publications

Product: Gericke, Smith, Moore et al.: "Adipocyte fatty acid-binding protein: interaction with phospholipid membranes and thermal stability studied by FTIR spectroscopy." in: Biochemistry, Vol. 36, Issue 27, pp. 8311-7, 1997 (PubMed).

Tuncman, Erbay, Hom et al.: "A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 18, pp. 6970-5, 2006 (PubMed).