FABP4 antibody

Catalog No. ABIN969126

Product Details anti-FABP4 Antibody

Target: FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FABP4 antibody is un-conjugated

Application: ELISA

Purpose: FABP4 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of FABP4 expressed in E. Coli.

Clone: 9B8D

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FABP4 antibody (ABIN969126)

Tuncman, Erbay, Hom, De Vivo, Campos, Rimm, Hotamisligil: "A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 18, pp. 6970-5, (2006) (PubMed).

Gericke, Smith, Moore, Mendelsohn, Storch: "Adipocyte fatty acid-binding protein: interaction with phospholipid membranes and thermal stability studied by FTIR spectroscopy." in: Biochemistry, Vol. 36, Issue 27, pp. 8311-7, (1997) (PubMed).

Target Details for FABP4

Target: FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))

Alternative Name: FABP4 (FABP4 Products)

Background:

Description: Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long chain fatty acids, their coenzymes and other hydrophobic ligands and small molecules in the cytoplasm. It is thought that the role of these proteins includes fatty acid uptake, intracellular lipid transport and metabolism. FABP4 encodes the fatty acid binding protein found in adipocytes. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders.

Aliases: aP2, A-FABP, FABP4

Molecular Weight: 14kDa

Gene ID: 2167

HGNC: 2167

UniProt: P15090

Pathways: Brown Fat Cell Differentiation