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Details for Product No. ABIN969217

Inhibin, alpha (INHA) antibody

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Antigen
Synonyms AW555078, si:dkey-91f15.2, INHA, MGC108500
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 1 reference available
Catalog no. ABIN969217
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human INHA expressed in E. coli.
Clone 4-00E-02
Isotype IgG1
Purification Ascites
Alternative Name INHA
Background Synonyms:
INHA
Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibins are also involved in regulating diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins, as inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibin has 2 subunits (α and β) that are coded by separate genes. The α subunit determines whether inhibin or activin will be produced. The α subunit remains constant, such that the various types of inhibin are defined by the β subunit (a,b,c,d). Inhibin A is a dimer of α and β A. Inhibin B is a dimer of α and β B. Proteolytic processing yields a number of inhibin α bioactive forms: the 20/23 kDa forms consist solely of the mature α chain, the 26/29 kDa forms consist of the most N terminal propeptide linked through a disulfide bond to the mature α chain, and the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono or diglycosylated, causing the mass difference.
Molecular Weight 40 kDa
Gene ID 3623
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Palmieri, Wilson, Iversen et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, 2008 (PubMed).

Alternatives for antigen "Inhibin, alpha (INHA)", type "Antibodies"
Hosts (101), (35), (2)
Reactivities (102), (36), (32), (13), (10), (8), (6)
Applications (70), (63), (55), (30), (30), (23), (21), (12), (7), (4), (2)
Conjugates (11), (11), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (15), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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