Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN969221

Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) antibody

Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms FNRA, CD49e, VLA5A, Cd49e, Fnra, VLA5, Itga5_retired, ITGA5, CD11c
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)
Pubmed 5 references available
Catalog no. ABIN969221
Quantity 100 µL
363.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human ITGA5 expressed in E. coli.
Clone 10F6
Isotype IgG2a
Purification Ascites
Alternative Name ITGA5
Background Synonyms:
The product of this gene belongs to the integrin α chain family. Integrins are heterodimeric integral membrane proteins composed of an α chain and a β chain. This gene encodes the integrin α 5 chain. α chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with β 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin α 5 is a heterodimer that associates noncovalently with CD29/integrin β 1 subunit to form the α-5-β-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-γ-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
Molecular Weight 114 kDa
Gene ID 3678
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Jones, Gockerman, Busby et al.: "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 22, pp. 10553-7, 1993 (PubMed).

Byzova, Plow: "Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin." in: The Journal of cell biology, Vol. 143, Issue 7, pp. 2081-92, 1999 (PubMed).

Wong, Wiedle, Ballestrem et al.: "PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis." in: Molecular biology of the cell, Vol. 11, Issue 9, pp. 3109-21, 2000 (PubMed).

Zhao, Newman: "Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell." in: The Journal of cell biology, Vol. 152, Issue 1, pp. 65-73, 2001 (PubMed).

Mould, Askari, Barton et al.: "Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19800-5, 2002 (PubMed).

Alternatives for antigen "Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5)", type "Antibodies"
Hosts (54), (52), (45), (42)
Reactivities (121), (94), (37), (14), (12), (3)
Applications (145), (49), (32), (27), (26), (19), (19), (15), (14), (10), (10), (3), (1), (1)
Conjugates (34), (21), (13), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (4), (4), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)