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Kelch-Like 1 (Drosophila) (KLHL1) antibody
|Synonyms||MRP2, FLJ30047, KIAA1490|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|3 references available|
|Price||363.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 3 to 4 Business Days|
|Immunogen||Purified recombinant fragment of human KLHL1 expressed in E. Coli.|
The mammalian Kelch like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin organizing proteins. Based on the presence of anti sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.Tissue specificity: Highly expressed in brain.
Synonyms: MRP2, FLJ30047, KIAA1490, KLHL1
Western Blotting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Buffer||Ascitic fluid containing 0.03% sodium azide.|
|Preservative||0.03% sodium azide|
|Storage||Store at 4℃, for long term storage, store at -20℃.|
|Research Area||Signaling, Cytoskeleton, Microfilaments|
|Restrictions||For Research Use only|
Nagase, Kikuno, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 2, pp. 143-50, 2000 (PubMed).
Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).
Barrios-Rodiles, Brown, Ozdamar et al.: "High-throughput mapping of a dynamic signaling network in mammalian cells." in: Science (New York, N.Y.), Vol. 307, Issue 5715, pp. 1621-5, 2005 (PubMed).
|Hosts||Rabbit (15), Mouse (2)|
|Reactivities||Human (14), Rat (Rattus) (5), Chicken (1), Cow (Bovine) (1), Fruit Fly (Drosophila melanogaster) (1), Mouse (Murine) (1), Xenopus laevis (1), Zebrafish (1)|
|Applications||Western Blotting (WB) (17), ELISA (7), Immunohistochemistry (IHC) (3), Immunofluorescence (IF) (2)|
|Epitopes||N-Term (4), C-Term (2), Internal Region (1)|