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Kelch-Like 1 (Drosophila) (KLHL1) antibody

Details for Product No. ABIN969241, Supplier: Login to see
Antigen
  • mKIAA1490
  • MRP2
Reactivity
Human
57
13
12
3
2
2
2
2
1
1
1
1
1
1
Host
Mouse
47
12
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
55
37
9
6
3
3
Supplier
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Immunogen Purified recombinant fragment of human KLHL1 expressed in E. coli.
Clone 3A8
Isotype IgG1
Purification Ascites
Alternative Name KLHL1 (KLHL1 Antibody Abstract)
Background The mammalian Kelch like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin organizing proteins. Based on the presence of anti sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.Tissue specificity: Highly expressed in brain.
Molecular Weight 82 kDa
Gene ID 57626
HGNC 57626
Research Area Signaling, Cytoskeleton, Microfilaments
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunocytochemistry (ICC) image for anti-Kelch-Like 1 (Drosophila) (KLHL1) antibody (ABIN969241) Figure 1: Immunofluorescence analysis of NIH/3T3 cells using KLHL1 mouse mAb (green) ...
Western Blotting (WB) image for anti-Kelch-Like 1 (Drosophila) (KLHL1) antibody (ABIN969241) Figure 2: Western blot analysis using KLHL1 mAb against human KLHL1 (AA: 202-506) rec...
Product cited in: Barrios-Rodiles, Brown, Ozdamar et al.: "High-throughput mapping of a dynamic signaling network in mammalian cells." in: Science (New York, N.Y.), Vol. 307, Issue 5715, pp. 1621-5, 2005 (PubMed).

Background publications Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Nagase, Kikuno, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 2, pp. 143-50, 2000 (PubMed).