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Details for Product No. ABIN969250

Keratin 15 (KRT15) antibody

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Antigen
Synonyms K15, CK15, K1CO, Krt1-15, AI528832, Ka15, zgc:55334, wu:fa91c06, wu:fa95d04, xlk2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
Pubmed 3 references available
Catalog no. ABIN969250
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of KRT15 expressed in E. coli.
Clone 6-00E-07
Isotype IgG2a
Purification Ascites
Alternative Name KRT15
Background Synonyms:
K15, CK15, K1CO, KRT1
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fηl epidermis and fηl nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.
Molecular Weight 49 kDa
Gene ID 3866
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Waseem, Dogan, Tidman et al.: "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes." in: The Journal of investigative dermatology, Vol. 112, Issue 3, pp. 362-9, 1999 (PubMed).

Werner, Munz: "Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo." in: Experimental cell research, Vol. 254, Issue 1, pp. 80-90, 2000 (PubMed).

Radoja, Stojadinovic, Waseem et al.: "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription." in: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3168-79, 2004 (PubMed).

Alternatives for antigen "Keratin 15 (KRT15)", type "Antibodies"
Hosts (70), (27), (7)
Reactivities (94), (48), (48), (36), (29), (17), (12), (2), (2)
Applications (58), (30), (30), (26), (24), (20), (19), (17), (4), (3), (3), (3), (2)
Conjugates (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (14), (3), (3), (2), (2), (1)
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