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Keratin 15 (KRT15) antibody

Details for Product No. ABIN969250
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Antigen
Synonyms K15, CK15, K1CO, Krt1-15, AI528832, Ka15, zgc:55334, wu:fa91c06, wu:fa95d04, xlk2
Reactivity
Human
(99), (52), (50), (35), (29), (17), (12), (2), (2)
Host
Mouse
(73), (27), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
(63), (32), (30), (30), (24), (20), (17), (11), (8), (3), (2)
Pubmed 3 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 3 to 4 Business Days
Catalog No. ABIN969250
363.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of KRT15 expressed in E. coli.
Clone 6-00E-07
Isotype IgG2a
Purification Ascites
Alternative Name KRT15
Background Synonyms:
K15, CK15, K1CO, KRT1
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fηl epidermis and fηl nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.
Molecular Weight 49 kDa
Gene ID 3866
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Keratin 15 (KRT15) antibody Figure 4: Flow cytometric analysis of PACN-1 cells using KRT15 mouse mAb (green) and negative control (purple) .
anti-Keratin 15 (KRT15) antibody (2) Figure 3: Immunofluorescence analysis of HepG2 (left) and PACN-1 (right) cells using KRT15 mouse mAb (green) . Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
anti-Keratin 15 (KRT15) antibody (3) Figure 2: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using KRT15 mouse mAb
anti-Keratin 15 (KRT15) antibody (4) Figure 1: Western blot analysis using KRT15 mouse mAb against A431 cell lysate.
Product cited in: Waseem, Dogan, Tidman et al.: "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes." in: The Journal of investigative dermatology, Vol. 112, Issue 3, pp. 362-9, 1999 (PubMed).

Werner, Munz: "Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo." in: Experimental cell research, Vol. 254, Issue 1, pp. 80-90, 2000 (PubMed).

Radoja, Stojadinovic, Waseem et al.: "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription." in: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3168-79, 2004 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN969250
363.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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