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KSHVORF62 antibody

Details for Product No. ABIN969255, Supplier: Log in to see
Antigen
Reactivity
Kaposi's Sarcoma-associated Herpesvirus (KSHV)
3
1
1
1
Host
Mouse
5
Clonality (Clone)
Monoclonal ()
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
6
5
2
1
1
Options
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Pubmed
5 references available

Available images

Immunohistochemistry (IHC) image for anti-KSHVORF62 antibody (ABIN969255)
Western Blotting (WB) image for anti-KSHVORF62 antibody (ABIN969255)
Immunogen Purified recombinant fragment of human KSHV ORF62 expressed in E. coli.
Clone 5B7B6
Isotype IgM
Purification Ascites
Background Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.
Gene ID 4961461
HGNC 4961461
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunohistochemistry (IHC) image for anti-KSHVORF62 antibody (ABIN969255) Figure 1: Immunocytochemistry analysis of TPA induced BCBL-1 cells (A) and uninduced ...
Western Blotting (WB) image for anti-KSHVORF62 antibody (ABIN969255) Figure 2: Western blot analysis using KSHV ORF62 mouse mAb against KSHV ORF62 recombi...
Product cited in: Holyfield: "Spit Tobacco Prevention Network (STOPN)." in: Texas nursing, Vol. 74, Issue 10, pp. 9, 2002 (PubMed).

Wu, Lo, Yu, Stoops, Forghani, Zhou: "Three-dimensional structure of the human herpesvirus 8 capsid." in: Journal of virology, Vol. 74, Issue 20, pp. 9646-54, 2000 (PubMed).

Nakamura, Oguri, Tabe, Igari: "[Epidemiological study on Staphylococcus epidermidis isolated from bloodstream and blood vessel catheter]." in: Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 74, Issue 2, pp. 96-103, 2000 (PubMed).

Background publications Russo, Bohenzky, Chien, Chen, Yan, Maddalena, Parry, Peruzzi, Edelman, Chang, Moore: "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 25, pp. 14862-7, 1997 (PubMed).

Chang, Cesarman, Pessin, Lee, Culpepper, Knowles, Moore: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." in: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, 1995 (PubMed).