p63alpha antibody

Details for Product No. ABIN969337
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Human, Mouse (Murine), Rat (Rattus), Monkey
(2), (1), (1), (1)
Clonality (Clone)
Monoclonal ()
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(2), (2), (2)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN969337
430.10 $
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Immunogen Synthesized peptide of human p63a.
Clone 4-00E-05
Isotype IgG1
Purification Ascites
Background Synonyms:
P51B, KET, p63a
The p63 gene is a homologue of the p53 tumor suppressor gene. Like p53, p63 contains a transactivation (TA) domain induce the transcription of target genes, a DNA binding domain, and an oligomerization domain (OD), used to form tetramers. In contrast to p53, the p63 gene encodes for at least six major isotypes. Three isotypes (TAp63α, TAp63β, and TAp63γ) contain the transactivating (TA) domain and are able to transactivate p53 report genes and induce apoptosis. In contrast, the other three isotypes (ΔNp63α, Δnp63β, ΔNp63γ) are transcribed from an internal promoter localized within intron3, lack the TA domain, and act as dominant-negatives to suppress transactivation by both p53 and TAp63 isotypes. p63 is highly expressed in the basal cells of the epithelium significant for proper limb outgrowth and morphogenesis. 4 In differentiating tissues, p63 is crucial for maintaining the stem cell identity of the basal cells, and is indispensable for correct development of the skin as well as the limb. p63-deficient mice lack all squamous epithelia and their derivatives, including hair, whiskers, teeth, as well as mammary, lacrimal, and salivary glands. Tissue specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skelηl muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of δN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
Molecular Weight 51 kDa
Gene ID 8626
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-p63alpha antibody Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng)
anti-p63alpha antibody (2) Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) and lung cancer (right) using p63α mouse mAb with DAB staining.
anti-p63alpha antibody (3) Figure 1: Western blot analysis using p63α mouse mAb against A431 (1), Hela (2), Jurkat (3), THP-1 (4), NIH/3T3 (5), Cos7 (6) and PC-12 (7) cell lysate.
Product cited in: Valenzise, Arrigo, De Luca et al.: "R298Q mutation of p63 gene in autosomal dominant ectodermal dysplasia associated with arrhythmogenic right ventricular cardiomyopathy." in: European journal of medical genetics, Vol. 51, Issue 5, pp. 497-500, 2008 (PubMed).

King, Ponnamperuma, Allen et al.: "The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth." in: Cancer research, Vol. 68, Issue 13, pp. 5122-31, 2008 (PubMed).

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