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We show that BIRC3 (show BIRC3 ELISA Kits) has a unique role in facilitating glioma progression from low- to high-grade
These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (show MAPK1 ELISA Kits) signaling by suppressing Pellino 1 (show PELI1 ELISA Kits)-mediated K63-linked ubiquitination of cIAP2 (show BIRC3 ELISA Kits), K48-linked ubiquitination, and degradation of TRAF3 (show TRAF3 ELISA Kits).
Birc3 (show BIRC3 ELISA Kits)-deficient mice are resistant to azoxymethane-sodium dodecyl sulfate-induced colitis-associated colorectal cancer.
c-IAP (show ALPI ELISA Kits) ubiquitin protein ligase (show UBE2K ELISA Kits) activity is required for 4-1BB (show TNFRSF9 ELISA Kits) signaling and CD8 (show CD8A ELISA Kits)(+) memory T-cell survival.
Induction of cIAP2 expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit.
Results identify IGF2BP1 (show B4GALNT2 ELISA Kits) as a critical translational regulator of cIAP1-mediated apoptotic resistance in rhabdomyosarcoma.
we show that cIAP1 regulates TNF (show TNF ELISA Kits)-induced actin cytoskeleton reorganization through a cdc42 (show CDC42 ELISA Kits)-dependentpathway
Identify xIAP (show XIAP ELISA Kits) and cIAP1 as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.
cIAP2 (Birc3 (show BIRC3 ELISA Kits))-dependent antagonism of RIPK3 (show RIPK3 ELISA Kits)-mediated programmed necrosis critically protects the host from influenza infection through maintenance of pulmonary tissue homeostasis.
cIAP-2 (show BIRC3 ELISA Kits) protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 (show MAPK1/3 ELISA Kits) MAPK (show MAPK1 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits).
High cIAP1 expression is associated with Lung Tumorigenesis.
These data suggest that molluscum contagiosum virus MC159 competitively binds to NEMO (show IKBKG ELISA Kits) to prevent cIAP1-induced NEMO (show IKBKG ELISA Kits) polyubiquitination.
The baseline tumor necrosis factor (show TNF ELISA Kits) tumor (TNFalpha (show TNF ELISA Kits)) expression correlates with the sensitivity to Inhibitors of apoptosis proteins (IAPs) antagonist T-3256336.
cIAP1-induced mitophagy led to dysfunctional mitochondria that resulted in abrogation of mitochondrial oxygen consumption rate along with the decrease in ATP levels. The ubiquitination of cIAP1 was found to be the critical regulator of mitophagy.
Overexpression of cIAP1 is associated with glioma.
High expression of cIAP1 is associated with triple-negative breast cancer.
cIAP1 and cIAP2 (show BIRC3 ELISA Kits) mediate BCL10 (show BCL10 ELISA Kits) ubiquitination essential for BCR (show BCR ELISA Kits)-dependent NF-kB activity in the ABC (show ABCB6 ELISA Kits) subtype of DLBCL. cIAP1/2 attach K63-linked polyubiquitin (show UBB ELISA Kits) chains on themselves and on BCL10 (show BCL10 ELISA Kits), recruiting IKK (show CHUK ELISA Kits) and LUBAC essential for IKK (show CHUK ELISA Kits) activation.
AZD5582 draws Mcl-1 (show MCL1 ELISA Kits) down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP (show XIAP ELISA Kits) in human pancreatic cancer
Data indicate that Smac/DIABLO (show DIABLO ELISA Kits) showed an inverse correlation with inhibitor of apoptosis proteins XIAP (show XIAP ELISA Kits), cIAP-1 and cIAP-2 (show BIRC3 ELISA Kits).
Data show that ectopic expression of interferon regulatory factor 1 (IRF-1 (show IRF1 ELISA Kits)) reduces NF-kappa B (show NFKB1 ELISA Kits) activity and suppresses TNF receptor-associated factor 2 (TRAF2 (show TRAF2 ELISA Kits)) and inhibitor of apoptosis 1 protein (cIAP1) expression in breast cancer cells.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, apoptosis inhibitor 1
, baculoviral IAP repeat-containing 2
, baculoviral IAP repeat-containing protein 3
, inhibitor of apoptosis protein 1
, inhibitor of apoptosis protein-1
, IAP homolog B
, NFR2-TRAF signalling complex protein
, RING finger protein 48
, TNFR2-TRAF-signaling complex protein 2
, baculoviral IAP repeat-containing protein 2
, inhibitor of apoptosis protein 2
, IAP homolog
, inhibitor of T-cell apoptosis protein
, inhibitor of apoptosis 1
, inhibitor of apoptosis protein
, apoptosis inhibitor 2
, baculoviral IAP repeat-containing 3