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Browse our BIRC2 Proteins (BIRC2)

Full name:
Baculoviral IAP Repeat Containing 2 Proteins (BIRC2)
On are 10 Baculoviral IAP Repeat Containing 2 (BIRC2) Proteins from 6 different suppliers available. Additionally we are shipping BIRC2 Antibodies (105) and BIRC2 Kits (6) and many more products for this protein. A total of 130 BIRC2 products are currently listed.
API1, Api2, AW107670, AW146227, Birc2, Birc3, c-IAP1, ciap-1, cIAP-2, cIAP1, cIAP2, Hiap-2, HIAP1, HIAP2, IAP1, IAP2, ITA, mcIAP1, MIAP1, MIAP2, MIHB, MIHC, RGD1559914, rIAP1, RNF48, RNF49
list all proteins Gene Name GeneID UniProt
BIRC2 11796 O08863
BIRC2 329 Q13490
Rat BIRC2 BIRC2 60371  

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BIRC2 Proteins (BIRC2) by Origin

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Top referenced BIRC2 Proteins

  1. Human BIRC2 Protein expressed in Escherichia coli (E. coli) - ABIN2003966 : Blankenship, Varfolomeev, Goncharov, Fedorova, Kirkpatrick, Izrael-Tomasevic, Phu, Arnott, Aghajan, Zobel, Bazan, Fairbrother, Deshayes, Vucic: Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1). in The Biochemical journal 2008 (PubMed)
    Show all 2 references for ABIN2003966

More Proteins for BIRC2 Interaction Partners

Mouse (Murine) Baculoviral IAP Repeat Containing 2 (BIRC2) interaction partners

  1. Birc3 (show BIRC3 Proteins)-deficient mice are resistant to azoxymethane-sodium dodecyl sulfate-induced colitis-associated colorectal cancer.

  2. c-IAP (show ALPI Proteins) ubiquitin protein ligase (show UBE2K Proteins) activity is required for 4-1BB (show TNFRSF9 Proteins) signaling and CD8 (show CD8A Proteins)(+) memory T-cell survival.

  3. Induction of cIAP2 expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit.

  4. Results identify IGF2BP1 (show B4GALNT2 Proteins) as a critical translational regulator of cIAP1-mediated apoptotic resistance in rhabdomyosarcoma.

  5. we show that cIAP1 regulates TNF (show TNF Proteins)-induced actin cytoskeleton reorganization through a cdc42 (show CDC42 Proteins)-dependentpathway

  6. Identify xIAP (show XIAP Proteins) and cIAP1 as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.

  7. cIAP2 (Birc3 (show BIRC3 Proteins))-dependent antagonism of RIPK3 (show RIPK3 Proteins)-mediated programmed necrosis critically protects the host from influenza infection through maintenance of pulmonary tissue homeostasis.

  8. cIAP-2 (show BIRC3 Proteins) protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins).

  9. these results show that the loss of cIAP1 protects skeletal muscle from the degenerative pathology resulting from systemic loss of dystrophin (show DMD Proteins).

  10. a molecular mechanism for cIAP1's regulation in the NOD2 signaling pathway

Human Baculoviral IAP Repeat Containing 2 (BIRC2) interaction partners

  1. Overexpression of cIAP1 is associated with glioma.

  2. High expression of cIAP1 is associated with triple-negative breast cancer.

  3. cIAP1 and cIAP2 (show BIRC3 Proteins) mediate BCL10 (show BCL10 Proteins) ubiquitination essential for BCR (show BCR Proteins)-dependent NF-kB activity in the ABC (show ABCB6 Proteins) subtype of DLBCL. cIAP1/2 attach K63-linked polyubiquitin (show UBB Proteins) chains on themselves and on BCL10 (show BCL10 Proteins), recruiting IKK (show CHUK Proteins) and LUBAC essential for IKK (show CHUK Proteins) activation.

  4. AZD5582 draws Mcl-1 (show MCL1 Proteins) down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP (show XIAP Proteins) in human pancreatic cancer

  5. Data indicate that Smac/DIABLO (show DIABLO Proteins) showed an inverse correlation with inhibitor of apoptosis proteins XIAP (show XIAP Proteins), cIAP-1 and cIAP-2 (show BIRC3 Proteins).

  6. Data show that ectopic expression of interferon regulatory factor 1 (IRF-1 (show IRF1 Proteins)) reduces NF-kappa B (show NFKB1 Proteins) activity and suppresses TNF receptor-associated factor 2 (TRAF2 (show TRAF2 Proteins)) and inhibitor of apoptosis 1 protein (cIAP1) expression in breast cancer cells.

  7. cIAP1 is associated with tumor progression in human ovarian cancer.

  8. The E3 ubiquitin ligase (show MUL1 Proteins) activity of XIAP (show XIAP Proteins) and cIAP1 activates NFkappaB (show NFKB1 Proteins) signalling, leading to the direct binding of p65 (show GORASP1 Proteins) to the promoter of Beclin 1 (show BECN1 Proteins) and to its transcriptional activation and induction of autophagy.

  9. CIAP1 and cIAP2 (show BIRC3 Proteins) represent novel therapeutic targets for the prevention of spontaneous preterm birth.

  10. Data suggest that the seventh zinc finger motif of DNA-binding protein (show UBE2V1 Proteins) A20 (show TNFAIP3 Proteins) plays important role in NFkappaB (show NFKB1 Proteins)-mediated apoptosis induced by tumor necrosis factor-alpha (show TNF Proteins); A20 (show TNFAIP3 Proteins) appears to bind and thus down-regulate inhibitor of apoptosis proteins cIAP1/2.

BIRC2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with BIRC2

  • baculoviral IAP repeat-containing 3 (Birc3)
  • inhibitor of apoptosis protein-1 (ciap-1)
  • baculoviral IAP repeat containing 2 (BIRC2)
  • baculoviral IAP repeat-containing 2 (Birc2)
  • NLR family, apoptosis inhibitory protein 5 (Naip5)
  • API1 protein
  • Api2 protein
  • AW107670 protein
  • AW146227 protein
  • Birc2 protein
  • Birc3 protein
  • c-IAP1 protein
  • ciap-1 protein
  • cIAP-2 protein
  • cIAP1 protein
  • cIAP2 protein
  • Hiap-2 protein
  • HIAP1 protein
  • HIAP2 protein
  • IAP1 protein
  • IAP2 protein
  • ITA protein
  • mcIAP1 protein
  • MIAP1 protein
  • MIAP2 protein
  • MIHB protein
  • MIHC protein
  • RGD1559914 protein
  • rIAP1 protein
  • RNF48 protein
  • RNF49 protein

Protein level used designations for BIRC2

IAP-1 , apoptosis inhibitor 1 , baculoviral IAP repeat-containing 2 , baculoviral IAP repeat-containing protein 3 , inhibitor of apoptosis protein 1 , mIAP-1 , inhibitor of apoptosis protein-1 , IAP homolog B , IAP-2 , NFR2-TRAF signalling complex protein , RING finger protein 48 , TNFR2-TRAF-signaling complex protein 2 , baculoviral IAP repeat-containing protein 2 , inhibitor of apoptosis protein 2 , IAP homolog , inhibitor of T-cell apoptosis protein , inhibitor of apoptosis 1 , inhibitor of apoptosis protein , apoptosis inhibitor 2 , baculoviral IAP repeat-containing 3 , mIAP-2

11796 Mus musculus
100304597 Ictalurus punctatus
329 Homo sapiens
374012 Gallus gallus
11797 Mus musculus
60371 Rattus norvegicus
294691 Rattus norvegicus
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