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Human BIRC2 Protein expressed in Escherichia coli (E. coli) - ABIN2003966
Blankenship, Varfolomeev, Goncharov, Fedorova, Kirkpatrick, Izrael-Tomasevic, Phu, Arnott, Aghajan, Zobel, Bazan, Fairbrother, Deshayes, Vucic: Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1). in The Biochemical journal 2008
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We show that BIRC3 (show BIRC3 Proteins) has a unique role in facilitating glioma progression from low- to high-grade
These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (show MAPK1 Proteins) signaling by suppressing Pellino 1 (show PELI1 Proteins)-mediated K63-linked ubiquitination of cIAP2 (show BIRC3 Proteins), K48-linked ubiquitination, and degradation of TRAF3 (show TRAF3 Proteins).
Birc3 (show BIRC3 Proteins)-deficient mice are resistant to azoxymethane-sodium dodecyl sulfate-induced colitis-associated colorectal cancer.
c-IAP (show ALPI Proteins) ubiquitin protein ligase (show UBE2K Proteins) activity is required for 4-1BB (show TNFRSF9 Proteins) signaling and CD8 (show CD8A Proteins)(+) memory T-cell survival.
Induction of cIAP2 expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit.
Results identify IGF2BP1 (show B4GALNT2 Proteins) as a critical translational regulator of cIAP1-mediated apoptotic resistance in rhabdomyosarcoma.
we show that cIAP1 regulates TNF (show TNF Proteins)-induced actin cytoskeleton reorganization through a cdc42 (show CDC42 Proteins)-dependentpathway
Identify xIAP (show XIAP Proteins) and cIAP1 as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.
cIAP2 (Birc3 (show BIRC3 Proteins))-dependent antagonism of RIPK3 (show RIPK3 Proteins)-mediated programmed necrosis critically protects the host from influenza infection through maintenance of pulmonary tissue homeostasis.
cIAP-2 (show BIRC3 Proteins) protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins).
High cIAP1 expression is associated with Lung Tumorigenesis.
These data suggest that molluscum contagiosum virus MC159 competitively binds to NEMO (show IKBKG Proteins) to prevent cIAP1-induced NEMO (show IKBKG Proteins) polyubiquitination.
The baseline tumor necrosis factor (show TNF Proteins) tumor (TNFalpha (show TNF Proteins)) expression correlates with the sensitivity to Inhibitors of apoptosis proteins (IAPs) antagonist T-3256336.
cIAP1-induced mitophagy led to dysfunctional mitochondria that resulted in abrogation of mitochondrial oxygen consumption rate along with the decrease in ATP levels. The ubiquitination of cIAP1 was found to be the critical regulator of mitophagy.
Overexpression of cIAP1 is associated with glioma.
High expression of cIAP1 is associated with triple-negative breast cancer.
cIAP1 and cIAP2 (show BIRC3 Proteins) mediate BCL10 (show BCL10 Proteins) ubiquitination essential for BCR (show BCR Proteins)-dependent NF-kB activity in the ABC (show ABCB6 Proteins) subtype of DLBCL. cIAP1/2 attach K63-linked polyubiquitin (show UBB Proteins) chains on themselves and on BCL10 (show BCL10 Proteins), recruiting IKK (show CHUK Proteins) and LUBAC essential for IKK (show CHUK Proteins) activation.
AZD5582 draws Mcl-1 (show MCL1 Proteins) down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP (show XIAP Proteins) in human pancreatic cancer
Data indicate that Smac/DIABLO (show DIABLO Proteins) showed an inverse correlation with inhibitor of apoptosis proteins XIAP (show XIAP Proteins), cIAP-1 and cIAP-2 (show BIRC3 Proteins).
Data show that ectopic expression of interferon regulatory factor 1 (IRF-1 (show IRF1 Proteins)) reduces NF-kappa B (show NFKB1 Proteins) activity and suppresses TNF receptor-associated factor 2 (TRAF2 (show TRAF2 Proteins)) and inhibitor of apoptosis 1 protein (cIAP1) expression in breast cancer cells.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, apoptosis inhibitor 1
, baculoviral IAP repeat-containing 2
, baculoviral IAP repeat-containing protein 3
, inhibitor of apoptosis protein 1
, inhibitor of apoptosis protein-1
, IAP homolog B
, NFR2-TRAF signalling complex protein
, RING finger protein 48
, TNFR2-TRAF-signaling complex protein 2
, baculoviral IAP repeat-containing protein 2
, inhibitor of apoptosis protein 2
, IAP homolog
, inhibitor of T-cell apoptosis protein
, inhibitor of apoptosis 1
, inhibitor of apoptosis protein
, apoptosis inhibitor 2
, baculoviral IAP repeat-containing 3