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anti-Human BIRC5 Antibodies:
anti-Mouse (Murine) BIRC5 Antibodies:
anti-Rat (Rattus) BIRC5 Antibodies:
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Human Polyclonal BIRC5 Primary Antibody for WB - ABIN3043195
Li, Zhao, Lu, Li, Yang, Wu, Liu: Notch-1 signaling promotes the malignant features of human breast cancer through NF-?B activation. in PLoS ONE 2014
Show all 6 Pubmed References
Mouse (Murine) Polyclonal BIRC5 Primary Antibody for WB - ABIN3043511
Zhang, Lu, Hou, Hu, Wang: The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells. in Tumour biology 2014
Show all 6 Pubmed References
Human Polyclonal BIRC5 Primary Antibody for IHC (p), ELISA - ABIN3042792
Cai, Liu, Zhao, Wan, Hu, Zhou, Chen: Expressions of survivin and vascular endothelial growth factor in a Murine model of proliferative retinopathy. in International journal of ophthalmology 2012
Show all 4 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for FACS - ABIN4895256
Mera, Magnusson, Tarkowski, Bokarewa: Extracellular survivin up-regulates adhesion molecules on the surface of leukocytes changing their reactivity pattern. in Journal of leukocyte biology 2007
Show all 3 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for IF, IP - ABIN559893
Yamazaki, Fujiwara, Yukinaga, Ebisuya, Shiki, Kurihara, Kioka, Kambe, Nagao, Nishida, Masuda: The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression. in Molecular biology of the cell 2010
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Human Polyclonal BIRC5 Primary Antibody for CyTOF, FACS - ABIN4900855
Charalambous, Oks, Nchinda, Yamazaki, Steinman: Dendritic cell targeting of survivin protein in a xenogeneic form elicits strong CD4+ T cell immunity to mouse survivin. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 2 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for FACS - ABIN4895255
Perabo, Frössler, Landwehrs, Schmidt, von Rücker, Wirger, Müller: Indirubin-3'-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer. in Anticancer research 2006
Human Monoclonal BIRC5 Primary Antibody for CyTOF, FACS - ABIN4898957
Schneider, Costa, Legrand, Bigot, Lecleire, Grassi, Vannier, Vasse: In vitro secretion of matrix metalloprotease 9 is a prognostic marker in childhood acute lymphoblastic leukemia. in Leukemia research 2010
circulating Survivin in prostate cancer patients was higher compared to controls, with the highest levels in African-American (AA) patients. AA patients with prostate cancer contained higher amounts of extracellular vesicles (EVs) in their plasma and sera than European-American (EA) patients. EVs from AA patients with prostate cancer contained higher amounts of Survivin, XIAP (show XIAP Antibodies) and cIAP-2 (show BIRC3 Antibodies) than EVs from EA patients.
results indicate that survivin is of prognostic signi fi cance in patients with renal cell carcinoma (show MOK Antibodies)
The aim of this study was to compare the prognostic value of the histopathological grading and the conventional biomarker MIB-1 with expression of the anti-apoptotic protein survivin to see if this biomarker could complement recurrence prediction.
Data suggest that the first 22 bp of exon 3 in BIRC5 contain cis (show CISH Antibodies)-acting elements that enhance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform via exclusion/deletion of exon 3; Sam68 (show KHDRBS1 Antibodies) is a possible trans-acting factor that binds to this cis (show CISH Antibodies)-acting element and regulates exon 3 splicing. (BIRC5/survivin = baculoviral IAP repeat containing 5; Sam68 (show KHDRBS1 Antibodies) = GAP-associated tyrosine phosphoprotein p62 (show KHDRBS1 Antibodies))
our data suggest the existence of a novel pre-metastatic phase quiescent-breast cancer stem cells (Q-BCSCs) before epithelial to mesenchymal transition and SURVIVIN acts as a marker for Quiescent-BCSCs
Expressions of SDF-1 (show CXCL12 Antibodies), survivin and smac (show DIABLO Antibodies) were significantly higher in epithelial ovarian cancer tissue than those in normal tissue.
Survivin expression predicted disease-free survival in high grade papillary urothelial carcinomas.
G/G genotype of the survivin -31C/G polymorphism might be a risk factor for UC development.
Studies indicate that survivin expression was associated with more aggressive clinical features and predicted poor cancer-specific survival (CSS (show CMAS Antibodies)) and overall survival (OS) in patients with renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)).
This study shows that both survivin and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1 (show IDH1 Antibodies)-mutation status
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
Survivin also attenuates DNA damage related to PARP (show PARP1 Antibodies) activation and inhibits TNFalpha (show TNF Antibodies)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (show TGFB1 Antibodies) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (show GUSB Antibodies) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 Antibodies) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Antibodies)) cancer stem cell formation and cancer SCC (show CYP11A1 Antibodies) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 Antibodies) and ki67 (show MKI67 Antibodies).
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL (show PRL Antibodies)-mediated beta cell proliferation via Akt (show AKT1 Antibodies), STAT5 (show STAT5A Antibodies)-PIM (show PIM1 Antibodies) and ERK (show EPHB2 Antibodies) signalling pathways during pregnancy
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha