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Human BIRC5 ELISA Kit for Sandwich ELISA - ABIN2683544
Blanc-Brude, Yu, Simosa, Conte, Sessa, Altieri: Inhibitor of apoptosis protein survivin regulates vascular injury. in Nature medicine 2002
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ablation of Glut1 (show SLC2A1 ELISA Kits) attenuated apoptosis and increased drug resistance via upregulation of p-Akt (show AKT1 ELISA Kits)/p-GSK-3beta (show GSK3b ELISA Kits) (Ser9)/beta-catenin (show CTNNB1 ELISA Kits)/survivin.
Nuclear survivin expression correlates with endoglin (show ENG ELISA Kits)-assessed microvascularisation in laryngeal squamous cell carcinoma.
survivin expression modes and YAP (show YAP1 ELISA Kits) localization (Hippo pathway activation modes) were not correlated with survival. In addition, we confirmed that survivin small interference RNA (siRNA) transfection and YM155, an anti-survivin drug, elicited decreased nuclear survivin expression and cell proliferation in ISO-HAS-B cells which expressed survivin consistently
Survivin expression in lung squamous cell carcinoma was increased compared to normal tissue, and was unaffected by methylation status of the surviving gene.
Survivin gene promoter methylation was more frequent in gastric cancer patients than in controls.
These findings uncover the significance of Merlin (show NF2 ELISA Kits) protein expression and Survivin labeling index as prognosticators for poor clinical outcome in two independent Malignant pleural mesothelioma cohorts.
circulating Survivin in prostate cancer patients was higher compared to controls, with the highest levels in African-American (AA) patients. AA patients with prostate cancer contained higher amounts of extracellular vesicles (EVs) in their plasma and sera than European-American (EA) patients. EVs from AA patients with prostate cancer contained higher amounts of Survivin, XIAP (show XIAP ELISA Kits) and cIAP-2 (show BIRC3 ELISA Kits) than EVs from EA patients.
results indicate that survivin is of prognostic signi fi cance in patients with renal cell carcinoma
The aim of this study was to compare the prognostic value of the histopathological grading and the conventional biomarker MIB-1 with expression of the anti-apoptotic protein survivin to see if this biomarker could complement recurrence prediction.
Data suggest that the first 22 bp of exon 3 in BIRC5 contain cis (show CISH ELISA Kits)-acting elements that enhance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform via exclusion/deletion of exon 3; Sam68 (show KHDRBS1 ELISA Kits) is a possible trans-acting factor that binds to this cis (show CISH ELISA Kits)-acting element and regulates exon 3 splicing. (BIRC5/survivin = baculoviral IAP repeat containing 5; Sam68 (show KHDRBS1 ELISA Kits) = GAP-associated tyrosine phosphoprotein p62 (show KHDRBS1 ELISA Kits))
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
HDL (show HSD11B1 ELISA Kits)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 (show STAT3 ELISA Kits) activity and survivin expression.
Survivin also attenuates DNA damage related to PARP (show PARP1 ELISA Kits) activation and inhibits TNFalpha (show TNF ELISA Kits)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (show TGFB1 ELISA Kits) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (show GUSB ELISA Kits) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 ELISA Kits) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 ELISA Kits)) cancer stem cell formation and cancer SCC (show CYP11A1 ELISA Kits) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 ELISA Kits) and ki67 (show MKI67 ELISA Kits).
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha