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Human BIRC5 ELISA Kit for Sandwich ELISA - ABIN2683544
Blanc-Brude, Yu, Simosa, Conte, Sessa, Altieri: Inhibitor of apoptosis protein survivin regulates vascular injury. in Nature medicine 2002
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circulating Survivin in prostate cancer patients was higher compared to controls, with the highest levels in African-American (AA) patients. AA patients with prostate cancer contained higher amounts of extracellular vesicles (EVs) in their plasma and sera than European-American (EA) patients. EVs from AA patients with prostate cancer contained higher amounts of Survivin, XIAP (show XIAP ELISA Kits) and cIAP-2 (show BIRC3 ELISA Kits) than EVs from EA patients.
results indicate that survivin is of prognostic signi fi cance in patients with renal cell carcinoma
The aim of this study was to compare the prognostic value of the histopathological grading and the conventional biomarker MIB-1 with expression of the anti-apoptotic protein survivin to see if this biomarker could complement recurrence prediction.
Data suggest that the first 22 bp of exon 3 in BIRC5 contain cis (show CISH ELISA Kits)-acting elements that enhance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform via exclusion/deletion of exon 3; Sam68 (show KHDRBS1 ELISA Kits) is a possible trans-acting factor that binds to this cis (show CISH ELISA Kits)-acting element and regulates exon 3 splicing. (BIRC5/survivin = baculoviral IAP repeat containing 5; Sam68 (show KHDRBS1 ELISA Kits) = GAP-associated tyrosine phosphoprotein p62 (show KHDRBS1 ELISA Kits))
our data suggest the existence of a novel pre-metastatic phase quiescent-breast cancer stem cells (Q-BCSCs) before epithelial to mesenchymal transition and SURVIVIN acts as a marker for Quiescent-BCSCs
Expressions of SDF-1 (show CXCL12 ELISA Kits), survivin and smac (show DIABLO ELISA Kits) were significantly higher in epithelial ovarian cancer tissue than those in normal tissue.
Survivin expression predicted disease-free survival in high grade papillary urothelial carcinomas.
G/G genotype of the survivin -31C/G polymorphism might be a risk factor for UC development.
Studies indicate that survivin expression was associated with more aggressive clinical features and predicted poor cancer-specific survival (CSS (show CMAS ELISA Kits)) and overall survival (OS) in patients with renal cell carcinoma (RCC (show XRCC1 ELISA Kits)).
This study shows that both survivin and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1 (show IDH1 ELISA Kits)-mutation status
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
Survivin also attenuates DNA damage related to PARP (show PARP1 ELISA Kits) activation and inhibits TNFalpha (show TNF ELISA Kits)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (show TGFB1 ELISA Kits) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (show GUSB ELISA Kits) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 ELISA Kits) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 ELISA Kits)) cancer stem cell formation and cancer SCC (show CYP11A1 ELISA Kits) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 ELISA Kits) and ki67 (show MKI67 ELISA Kits).
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL (show PRL ELISA Kits)-mediated beta cell proliferation via Akt (show AKT1 ELISA Kits), STAT5 (show STAT5A ELISA Kits)-PIM (show PIM1 ELISA Kits) and ERK (show EPHB2 ELISA Kits) signalling pathways during pregnancy
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha