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we discovered a novel mechanism mediated by Smad4 (show SMAD4 ELISA Kits) to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/CDC2 (show CDK1 ELISA Kits)/survivin cascade.
It also inhibits the mRNA levels of Survivin gene.
Overexpression of miR494 and silencing survivin RNA through the use of survivin shRNA inhibited the expression of survivin and attenuated PC3 (show PCSK1 ELISA Kits) cell growth in vitro and in vivo.
Expression of livin (show BIRC7 ELISA Kits), survivin and caspase-3 (show CASP3 ELISA Kits) are closely related to the occurrence and development of prostatic cancer.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 ELISA Kits)) cancer stem cell formation and cancer SCC (show CYP11A1 ELISA Kits) development.
results indicate that survivin functions as a common mediator of gemcitabine- and TRAIL-induced cell death.
We defined Survivin as a constitutive actor of HR in breast cancers, and implies that its inhibition would enhance cell vulnerability upon PARP (show COL11A2 ELISA Kits) inhibition.
Studies on survivin in NP cells may aid in increasing the understanding of the complex processes underlying NP cell degeneration, and could provide fundamental information for gene therapy to inhibit this degeneration in vitro
Suggest that the p53 (show TP53 ELISA Kits)-p21 (show CDKN1A ELISA Kits)-DREAM-CDE/CHR pathway regulates p53 (show TP53 ELISA Kits)-dependent repression of Survivin, CDC25C (show CDC25C ELISA Kits), and PLK1 (show PLK1 ELISA Kits) in HCT116 cells.
Overexpression of FOXM1 (show FOXM1 ELISA Kits), XIAP (show XIAP ELISA Kits), and Survivin contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients.
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 ELISA Kits) and ki67 (show MKI67 ELISA Kits).
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL (show PRL ELISA Kits)-mediated beta cell proliferation via Akt (show AKT1 ELISA Kits), STAT5 (show STAT5A ELISA Kits)-PIM (show PIM1 ELISA Kits) and ERK (show EPHB2 ELISA Kits) signalling pathways during pregnancy
Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.
Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury
NR4A1 (show NR4A1 ELISA Kits) protects pancreatic beta-cells against endoplasmic reticulum stress-mediated apoptosis by up-regulating Survivin expression and down-regulating CHOP (show DDIT3 ELISA Kits) expression.
Studies indicate the importance of survivin in Sonic hedgehog (SHH (show SHH ELISA Kits))-driven medulloblastoma (MB).
the Skp1 (show SKP1 ELISA Kits).Cul1 (show CUL1 ELISA Kits).F-box protein (show FBXO30 ELISA Kits) complex subunit Fbxl7 (show FBXL7 ELISA Kits) modulates mitochondrial function by controlling the cellular abundance of survivin
Both HIF1-alpha (show HIF1A ELISA Kits) and survivin are involved in the retinal neovascularization in oxygen-induced retinopathy.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha