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Browse our CAPN2 Proteins (CAPN2)

Full name:
Calpain 2, (M/II) Large Subunit Proteins (CAPN2)
On are 7 Calpain 2, (M/II) Large Subunit (CAPN2) Proteins from 5 different suppliers available. Additionally we are shipping CAPN2 Antibodies (30) and CAPN2 Kits (14) and many more products for this protein. A total of 52 CAPN2 products are currently listed.
AI326419, CANP2, CANP 2, CANPL2, CANPml, Capa-2, Capa2, m-calpain, m-calpin, mCANP
list all proteins Gene Name GeneID UniProt
CAPN2 12334 O08529
CAPN2 824 P17655
Rat CAPN2 CAPN2 29154 Q07009

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CAPN2 Proteins (CAPN2) by Origin

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More Proteins for CAPN2 Interaction Partners

Mouse (Murine) Calpain 2, (M/II) Large Subunit (CAPN2) interaction partners

  1. Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.

  2. LOX-1 (show OLR1 Proteins) is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 (show CAPN1 Proteins) and -2.

  3. Dicer is predominantly (show CA2 Proteins) a Capn2 substrate. Dicer levels were altered in platelets from diabetic mice due to the cleavage (show DICER1 Proteins) of the enzyme by calpain, resulting in loss of function.

  4. Data suggest that vitamin D3 up-regulates skeletal muscle fat deposition, up-regulates muscle m-calpain/Capn2 and u-calpain/Capn1 expression, and down-regulates muscle calpastatin expression.

  5. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 (show CAPN1 Proteins) deficient mice.

  6. Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 (show TMOD1 Proteins) and TMOD4 (show TMOD4 Proteins) leads to thin filament elongation in dystrophic skeletal muscle.

  7. extrasynaptic NMDAR (show GRIN1 Proteins)-coupled m-calpain activation is neurodegenerative

  8. Down-regulated expression of calpain-2 or talin-1, or pharmacological interference with calpain action, did not affect toxin binding but reduced endocytosis and increased the survival of cells exposed to anthrax lethal toxin.

  9. The carboxyl tail of alpha-actinin-4 (show ACTN4 Proteins) regulates its susceptibility to m-calpain and thus functions in cell migration and spreading.

  10. Calpain-2 was required for FFA-induced expression of CHOP (show DDIT3 Proteins) and activation of caspase-12 and caspase-3 (show CASP3 Proteins), thus promoting cell apoptosis in beta-TC3 cells.

Human Calpain 2, (M/II) Large Subunit (CAPN2) interaction partners

  1. our findings suggest that the gene/protein expression of both CAPN1 (show CAPNL1 Proteins) and CAPN2, as well as the ERK1 (show MAPK3 Proteins) and ERK2 (show MAPK1 Proteins) genes and related proteins, could be molecular factors associated with more invasive tumor behavior in squamous cell laryngeal cancer.

  2. Calpain 2-mediated cleavage of Atg3 (show ATG3 Proteins) and Atg7 (show ATG7 Proteins) accounts for the impaired autophagy.

  3. Calcineurin (show PPP3CA Proteins) together with its upstream molecule, calpain 2, and its downstream effector, NFAT (show NFATC1 Proteins)-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes.

  4. Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.

  5. Taken together, our results demonstrated the deregulation of GAS2 (show GAS2 Proteins) in both AML (show RUNX1 Proteins) and ALL and the requirement of GAS2 (show GAS2 Proteins)-Calpain2 axis for the growth of leukemic cells.

  6. The combination of Ca2 (show CA2 Proteins)+ and ionomycin was required to activate calpain 2, resulting in the further degradation of Dicer (show DICER1 Proteins) and the appearance of a degradation product similar to that detected in platelets from some diabetic individuals.

  7. In a transgenic mouse model, hypoxia-triggered m-calpain activation is involved in endoplasmic reticulum stress-mediated Alzheimer's disease pathogenesis.

  8. Small interfering RNA (siRNA)-mediated silencing of m-calpain expression significantly suppressed the adhesive, migrative and invasive potentials of human hepatoma cells.

  9. The data reveal that hGAAP is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca(2 (show CA2 Proteins)+)-dependent activation of calpain 2.

  10. The carboxyl tail of alpha-actinin-4 (show ACTN4 Proteins) regulates its susceptibility to m-calpain and thus functions in cell migration and spreading.

Cow (Bovine) Calpain 2, (M/II) Large Subunit (CAPN2) interaction partners

  1. m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.

  2. The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.

  3. The cleavage of NCX1 (show SLC8A1 Proteins) by m-calpain in the caveolae vesicles may be interpreted as an important mechanism of Ca(2 (show CA2 Proteins)+) overload

  4. characteristic properties of ER membrane m-calpain (MCp (show CD46 Proteins)), calpastatins and lumen m-calpain (LCp (show KLHDC2 Proteins)) and a brief comparative study between MCp (show CD46 Proteins) and LCp (show KLHDC2 Proteins)

Pig (Porcine) Calpain 2, (M/II) Large Subunit (CAPN2) interaction partners

  1. Calpain-2 plays an important role in lung endothelial cell migration and proliferation.

  2. The Decreased expression of calpain 2 mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.

CAPN2 Protein Profile

Protein Summary

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CAPN2

  • calpain 2 (Capn2)
  • calpain 2, (m/II) large subunit (CAPN2)
  • calpain 2, (m/II) large subunit (Capn2)
  • AI326419 protein
  • CANP2 protein
  • CANP 2 protein
  • CANPL2 protein
  • CANPml protein
  • Capa-2 protein
  • Capa2 protein
  • m-calpain protein
  • m-calpin protein
  • mCANP protein

Protein level used designations for CAPN2

80 kDa M-calpain subunit , CALP80 , CANP 2 , calcium-activated neutral proteinase 2 , calpain M-type , calpain-2 catalytic subunit , calpain-2 large subunit , cysteine proteinase , m-calpain 80 kDa large subunit , m-calpain large subunit , millimolar-calpain , M-calpain , calpain 2, large [catalytic] subunit , calpain 2, large subunit , calpain large polypeptide L2 , calpain, large polypeptide L2 , mCL , calpain II

12334 Mus musculus
824 Homo sapiens
29154 Rattus norvegicus
281662 Bos taurus
395963 Gallus gallus
397393 Sus scrofa
100009092 Oryctolagus cuniculus
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