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Browse our Caspase 2 (CASP2) ELISA Kits

Full name:
Caspase 2, Apoptosis-Related Cysteine Peptidase ELISA Kits (CASP2)
On are 21 Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) ELISA Kits from 9 different suppliers available. Additionally we are shipping Caspase 2 Antibodies (227) and Caspase 2 Proteins (21) and many more products for this protein. A total of 278 Caspase 2 products are currently listed.
CASP-2, Caspase-2, ICH-1, ICH-1L/1S, ICH1, ICH1L1S, NEDD-2, NEDD2, PPP1R57, xCaspase-2
list all ELISA KIts Gene Name GeneID UniProt
CASP2 64314 P55215
Mouse CASP2 CASP2 12366 P29594
CASP2 835 P42575

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Top referenced Caspase 2 ELISA Kits

  1. ABIN412025 : Espín, Roca, Candel, Sepulcre, González-Rosa, Alcaraz-Pérez, Meseguer, Cayuela, Mercader, Mulero: TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. in Disease models & mechanisms 2013 (PubMed)
    Show all 4 references for ABIN412025

  2. ABIN411819 : Ark, Ozdemir, Polat: Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2. in Apoptosis : an international journal on programmed cell death 2010 (PubMed)
    Show all 4 references for ABIN411819

  3. ABIN411815 : Sapet, Simoncini, Loriod, Puthier, Sampol, Nguyen, Dignat-George, Anfosso: Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. in Blood 2006 (PubMed)
    Show all 3 references for ABIN411815

More ELISA Kits for Caspase 2 Interaction Partners

Xenopus laevis Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. caspase-2 has a role as an initiator caspase (show CASP3 ELISA Kits) in lipoapoptosis

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (show BID ELISA Kits) and Caspases-2 and -8

  3. Caspase-2 phosphorylated at S135 binds 14-3-3zeta (show YWHAZ ELISA Kits), thus preventing C2 dephosphorylation.

  4. The data demonstrate that cell death is prevented during mitosis through the inhibitory phosphorylation of caspase-2 and suggest that under conditions of mitotic arrest, cdk1 (show CDK1 ELISA Kits)-cyclin B1 (show CCNB1 ELISA Kits) activity must be overcome for apoptosis to occur.

Mouse (Murine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. Caspase-2 deficiency protected mice from diet-induced obesity, metabolic syndrome and nonalcoholic fatty liver disease.

  2. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein (show HOMER1 ELISA Kits) Raidd (show CRADD ELISA Kits)

  3. Data show that indoles can effectively suppress acute hepatic inflammation caused by staphylococcal enterotoxin B (SEB) maybe mediated by decreased expression of miR-31 and caspase-2-dependent apoptosis in T cells.

  4. Data indicate that the nucleotide-binding domain and leucine-rich repeat containing (show NLRX1 ELISA Kits) (NLRP3 (show NLRP3 ELISA Kits))-caspase-2 axis drives general endoplasmic reticulum (ER) stress-induced inflammasome activation.

  5. these studies elucidate a Caspase-2-p53 (show TP53 ELISA Kits) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.

  6. data strongly suggest that caspase-2 deficiency leads to increased cellular stress largely because these mice fail to respond to oxidative stress by upregulating their antioxidant defense mechanism

  7. These results demonstrate an important role for caspase-2 in regulating proteome and metabolome remodelling during ageing.

  8. Caspase-2 is not a suppressor in MYCN (show MYCN ELISA Kits)-induced neuroblastoma (show ARHGEF16 ELISA Kits) and suggest a tissue and context-specific role for caspase-2 in tumorigenesis.

  9. our data point to a critical and novel role for caspase-2 in maintaining bone homeostasis by modulating ROS (show ROS1 ELISA Kits) levels and osteoclast apoptosis during conditions of enhanced oxidative stress that occur during aging

  10. Report the novel finding that CASP2 is an endogenous repressor of autophagy. Knockout or knockdown of CASP2 resulted in upregulation of autophagy in a variety of cell types and tissues.

Human Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. CASP2 down-regulation had a reverse relationship with miR (show MLXIP ELISA Kits)-383 down-regulation in regulating epithelial ovarian cancer development.

  2. Results suggest that mutations at all three cleavage sites of caspase-2 protein neither affect the macromolecular core complex assembly, nor modify caspase-2 activity upon DNA damage. Consequently, caspase-2 activation occurs in the macromolecular complex without its dissociation.

  3. These findings indicate that miR (show MLXIP ELISA Kits)-125a-5p decreases after HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.

  4. these studies elucidate a Caspase-2-p53 (show TP53 ELISA Kits) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.

  5. We have also demonstrated that these correlations are tissue specific being reduced (CASP9 (show CASP9 ELISA Kits) and CASP10 (show CASP10 ELISA Kits)) or different (CASP2) in the liver

  6. the initiator caspase-2 is required for robust death of ovarian cancer cells induced by FASN (show FASN ELISA Kits) inhibitors

  7. HuR (show ELAVL1 ELISA Kits) sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by upregulating the translation of caspase-2.

  8. Authors have demonstrated in vitro and in vivo that loss of function of caspase-2 allows to escape oncogenic stress induced senescence.

  9. Data strongly argue against a critical role for caspase-2 in ER-stress-induced apoptosis.

  10. axon regeneration promoted by suppression of CASP2 and CASP6 (show CASP6 ELISA Kits) is CNTF (show CNTF ELISA Kits)-dependent and mediated through the JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) signalling pathway

Cow (Bovine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. EtOH-induced mitochondria-mediated apoptosis is initiated by caspase-2 activation, which is regulated by CoQ10

  2. the capacity for blastocysts to undergo further development is related to degree of group II caspase (show CASP3 ELISA Kits) activity

Pig (Porcine) Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) interaction partners

  1. hypoxia/re-oxygenation injury in cultured proximal tubule cells induced apoptosis by activation of caspase-2, which is required for the mitochondrial translocation of Bax (show BAX ELISA Kits).

Caspase 2 (CASP2) Antigen Profile

Antigen Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Caspase 2 (CASP2)

  • caspase-2-like (LOC100050611) Elisa Kit
  • caspase-2 (xCaspase-2) Elisa Kit
  • caspase-2 (CpipJ_CPIJ008254) Elisa Kit
  • caspase 2 (Casp2) Elisa Kit
  • caspase 2 (LOC100101590) Elisa Kit
  • caspase 2, apoptosis-related cysteine peptidase (CASP2) Elisa Kit
  • caspase 2, apoptosis-related cysteine peptidase (Casp2) Elisa Kit
  • caspase-2-like (LOC100521118) Elisa Kit
  • CASP-2 Elisa Kit
  • Caspase-2 Elisa Kit
  • ICH-1 Elisa Kit
  • ICH-1L/1S Elisa Kit
  • ICH1 Elisa Kit
  • ICH1L1S Elisa Kit
  • NEDD-2 Elisa Kit
  • NEDD2 Elisa Kit
  • PPP1R57 Elisa Kit
  • xCaspase-2 Elisa Kit

Protein level used designations for CASP2

caspase-2 , CASP-2 , ICH-1 protease , protease ICH-1 , NEDD-2 , neural precursor cell expressed developmentally down-regulated protein 2 , protein phosphatase 1, regulatory subunit 57 , caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) , ICH1 protease , caspase 2, apoptosis-related cysteine protease , cysteine protease caspase-2

100050611 Equus caballus
397817 Xenopus laevis
6040179 Culex quinquefasciatus
64314 Rattus norvegicus
12366 Mus musculus
100101590 Oryctolagus cuniculus
835 Homo sapiens
482737 Canis lupus familiaris
531419 Bos taurus
395857 Gallus gallus
100735399 Cavia porcellus
100521118 Sus scrofa
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