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anti-Human EPR1 Antibodies:
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we discovered a novel mechanism mediated by Smad4 (show SMAD4 Antibodies) to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/CDC2 (show CDK1 Antibodies)/survivin (show BIRC5 Antibodies) cascade.
It also inhibits the mRNA levels of Survivin (show BIRC5 Antibodies) gene.
Overexpression of miR494 and silencing survivin (show BIRC5 Antibodies) RNA through the use of survivin (show BIRC5 Antibodies) shRNA inhibited the expression of survivin (show BIRC5 Antibodies) and attenuated PC3 (show PCSK1 Antibodies) cell growth in vitro and in vivo.
Expression of livin (show BIRC7 Antibodies), survivin (show BIRC5 Antibodies) and caspase-3 (show CASP3 Antibodies) are closely related to the occurrence and development of prostatic cancer.
Survivin (show BIRC5 Antibodies) is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Antibodies)) cancer stem cell formation and cancer SCC (show CYP11A1 Antibodies) development.
results indicate that survivin (show BIRC5 Antibodies) functions as a common mediator of gemcitabine- and TRAIL-induced cell death.
We defined Survivin (show BIRC5 Antibodies) as a constitutive actor of HR in breast cancers, and implies that its inhibition would enhance cell vulnerability upon PARP (show COL11A2 Antibodies) inhibition.
Studies on survivin (show BIRC5 Antibodies) in NP cells may aid in increasing the understanding of the complex processes underlying NP cell degeneration, and could provide fundamental information for gene therapy to inhibit this degeneration in vitro
Suggest that the p53 (show TP53 Antibodies)-p21 (show CDKN1A Antibodies)-DREAM-CDE/CHR pathway regulates p53 (show TP53 Antibodies)-dependent repression of Survivin (show BIRC5 Antibodies), CDC25C (show CDC25C Antibodies), and PLK1 (show PLK1 Antibodies) in HCT116 cells.
Overexpression of FOXM1 (show FOXM1 Antibodies), XIAP (show XIAP Antibodies), and Survivin (show BIRC5 Antibodies) contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
apoptosis inhibitor 4
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing protein 5
, survivin variant 3 alpha