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Browse our GZMA Proteins (GZMA)

Full name:
Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) Proteins (GZMA)
On are 14 Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) Proteins from 8 different suppliers available. Additionally we are shipping GZMA Antibodies (111) and GZMA Kits (23) and many more products for this protein. A total of 158 GZMA products are currently listed.
AW494114, Ctla-3, CTLA3, GZMA, Hf, HFSP, SE1, TSP-1, TSP1
list all proteins Gene Name GeneID UniProt
GZMA 14938 P11032
Rat GZMA GZMA 266708  
GZMA 3001 P12544

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GZMA Proteins (GZMA) by Origin

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Top referenced GZMA Proteins

  1. Human GZMA Protein expressed in HEK-293 - ABIN2666491 : Edwards, Kam, Powers, Trapani: The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. in The Journal of biological chemistry 1999 (PubMed)
    Show all 6 references for ABIN2666491

More Proteins for GZMA Interaction Partners

Mouse (Murine) Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) interaction partners

  1. Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis.

  2. The results, in susceptible B6 mice for GzmB and in resistant 129/Sv mice for GzmA and/or the GzmB cluster, point to granzyme-mediated host defense regulation in the liver in experimental visceral leishmaniasis.

  3. Estrogen increases the extracellular expression and interleukin (IL)-12 (show IL12A Proteins)-induced activity of a critical member of serine protease (show F2 Proteins) family granzyme A.

  4. functional divergence between human and mouse granzyme A

  5. Regulated secretion of granzyme A and cytotoxic killing was enhanced and correlated with increased vesicle-associated membrane protein 7 (show VAMP7 Proteins) availability.

  6. GzmA deficiency in filarial infection is linked with reduced inflammation and a trend toward increased alternatively activated macrophages.

  7. granzyme A- and B-cluster deficiency delays the acute progression of pneumovirus disease by reducing alveolar injury.

  8. the genes for perforin (show PRF1 Proteins), the three major T cell granzymes (A-C) and IFN-gamma (show IFNG Proteins) are differentially expressed during primary activation of naive CD8 (show CD8A Proteins)(+) T cells, kinetically and at the single-cell level

  9. granzyme A and granzyme B have a similar potential to induce rapid perf-mediated apoptosis but that their individual contribution to the underlying intracellular process is dictated by the quality of the target cell

  10. some cytolytic T lymphocytes mature into perforin (show PRF1 Proteins)/granzyme-expressing effector cells in the mediastinal lymph node and are detectable when they accumulate in lung infection

Human Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) interaction partners

  1. Our results suggest that granzyme A could be considered another biomarker of TB, that can be used, other than IFN-gamma (show IFNG Proteins), to discriminate between patients with active TB and LTBI subjects

  2. Delivered into parasite infected cells by granulysin (show GNLY Proteins) and perforin (show PRF1 Proteins), granzymes generate superoxide and inactivate oxidative defense enzymes to kill the parasite.

  3. Taken together, the authors verified that histone H3 (show HIST3H3 Proteins) is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin.

  4. Results reveal enhanced intra- and extracellular expression of gzmA and B in patients with pulmonary TB, suggesting that gzms are part of the host response to tuberculosis.

  5. Levels of GZMA and ITGAE (show ITGAE Proteins) mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients.

  6. GzmA and GzmB expressing cells in the airways and lung parenchyma was higher in subjects who died from asthma

  7. GZMA, GBP5 and CD64 (show FCGR1A Proteins) genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases.

  8. We herewith identify GZMA as critical effector molecule of human Treg function for gastrointestinal immune response in an experimental GvHD model.

  9. The exocytosed granzyme A enters target cells and mediates IL-1beta (show IL1B Proteins) maturation independently of caspase-1 (show CASP1 Proteins) and without inducing cytotoxicity.

  10. Serum concentrations of granzyme A in patients with ovarian cancer were substantially increased in comparison to concentrations in patients with ovarian cystadenomas or ovarian teratomas.

GZMA Protein Profile

Protein Summary

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.

Alternative names and synonyms associated with GZMA

  • granzyme A (gzmA)
  • granzyme A (GZMA)
  • Granzyme A (graa)
  • granzyme A (Gzma)
  • granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) (GZMA)
  • AW494114 protein
  • Ctla-3 protein
  • CTLA3 protein
  • GZMA protein
  • Hf protein
  • HFSP protein
  • SE1 protein
  • TSP-1 protein
  • TSP1 protein

Protein level used designations for GZMA

granzyme A , Granzyme A , BLT esterase , H factor , Hanukah factor , autocrine thymic lymphoma granzyme-like serine protease , fragmentin-1 , serine esterase 1 , t cell-specific serine protease 1 , CTL tryptase , Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease) , HF , cytotoxic T-lymphocyte proteinase 1 , h factor

407178 Bos taurus
100113480 Felis catus
100196008 Salmo salar
14938 Mus musculus
266708 Rattus norvegicus
3001 Homo sapiens
100526762 Sus scrofa
539093 Bos taurus
487207 Canis lupus familiaris
395108 Gallus gallus
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