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Results show that downregulation of DR4 and DR5 (show TNFRSF10B ELISA Kits) by SLC26A2 (show SLC26A2 ELISA Kits) confers resistance to TRAIL.
BAY61-3606 sensitizes colon cancer cells to TRAIL-induced apoptosis by up-regulating DR4 expression in p53 (show TP53 ELISA Kits)-dependent manner and inhibiting NF-kappaB (show NFKB1 ELISA Kits) activity.
findings together highlight a previously undiscovered mechanism that positively regulates DR4 expression through activation of the MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits)/AP-1 (show FOSB ELISA Kits) signaling pathway.
results suggest that the altered TRAIL, DR4 alleles and sTRAIL levels may be associated with some other potential biomarkers for vitiligo (show MITF ELISA Kits)
The nanovectorization of TRAIL enhanced its binding to both DR4 and DR5 (show TNFRSF10B ELISA Kits) receptors at 37 degrees C and could potentially sensitized cancer cells to TRAIL induced apoptosis through simultaneous activation of DR4 and DR5 (show TNFRSF10B ELISA Kits) as described in this paper for the non-small lung carcinoma cell line (H1703), the two hepatocarcinoma cell lines (SK-Hep1, HUH) and the colon carcinoma cell line (HCT116WT).
Pro-survival effects by NF-kappaB (show NFKB1 ELISA Kits), Akt (show AKT1 ELISA Kits) and ERK(1 (show MAPK3 ELISA Kits)/2) and anti-apoptosis actions by Six1 (show SIX1 ELISA Kits) disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer, which may explain why up-regulated DR4 and DR5 (show TNFRSF10B ELISA Kits) in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.
Bee venom inhibits colon cancer cell growth, and these anti-proliferative effects may be related to the induction of apoptosis by activation of DR4 and DR5 (show TNFRSF10B ELISA Kits) and inhibition of NF-kappaB (show NFKB1 ELISA Kits) activity.
study involving a relatively large sample size showed that TNFRSF10 eQTL (show EQTN ELISA Kits) SNPs within lncRNAs might influence both hepatocellular carcinoma development and HBV infection
Study investigated the association between colorectal cancer and polymorphisms in TRAIL and DR4 gene in Pakistani patients; TRAIL gene 1595 C>T genotypes percentage in colorectal cancer patients was statistically non-significant; for DR4 A1322G, homozygous GG genotype was 36% in the patients and in controls: there was statistically insignificant difference (p> 0.05).
TRAIL genetic polymorphisms do not contribute, but DR4 polymorphisms may contribute to susceptibility to head and neck cancer in Pakistani population.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
TNF-related apoptosis-inducing ligand receptor 1
, TRAIL receptor 1
, cytotoxic TRAIL receptor
, death receptor 4
, tumor necrosis factor receptor superfamily member 10A
, tumor necrosis factor receptor superfamily member 10a variant 2
, tumor necrosis factor receptor superfamily, member 10a
, tumor necrosis factor receptor superfamily member 10A-like