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anti-Human Beclin 1 Antibodies:
anti-Mouse (Murine) Beclin 1 Antibodies:
anti-Rat (Rattus) Beclin 1 Antibodies:
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Dog (Canine) Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN259945
Liang, Kleeman, Jiang, Gordon, Goldman, Berry, Herman, Levine: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. in Journal of virology 1998
Show all 31 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN153048
Gulati, Gaspers, Dann, Joaquin, Nobukuni, Natt, Kozma, Thomas, Thomas: Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. in Cell metabolism 2008
Show all 73 Pubmed References
Human Monoclonal Beclin 1 Primary Antibody for IHC, IHC (p) - ABIN314194
Ko, Lin, Flomenberg, Pestell, Howell, Sotgia, Lisanti, Martinez-Outschoorn: Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. in Cancer biology & therapy 2012
Show all 16 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IF (cc), IF (p) - ABIN675384
Tang, Li, Wei, Zhang, Chiu, Hasenmayer, Zhang, Zhang: Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. in Cancer letters 2013
Show all 8 Pubmed References
Human Monoclonal Beclin 1 Primary Antibody for IF, IHC (p) - ABIN387797
Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. in Human genetics 2010
Show all 9 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IHC (p), WB - ABIN388545
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
Show all 10 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for FACS, IHC (p) - ABIN388546
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
Show all 10 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IHC, IHC (p) - ABIN438264
Song, Qu, Guo, Zhao, Zhao, Gao, Sun, Shen, Wu, Wei: Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. in Autophagy 2009
Show all 3 Pubmed References
Monoclonal Beclin 1 Primary Antibody for IHC (fro), WB - ABIN534092
Aita, Liang, Murty, Pincus, Yu, Cayanis, Kalachikov, Gilliam, Levine: Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. in Genomics 1999
Show all 4 Pubmed References
Human Monoclonal Beclin 1 Primary Antibody for FACS, IHC - ABIN968976
Zhong, Wang, Li, Yan, Backer, Chait, Heintz, Yue: Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. in Nature cell biology 2009
Show all 3 Pubmed References
Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
ABHD5 (show ABHD5 Antibodies) possesses a PNPLA2 (show PNPLA2 Antibodies)-independent function in regulating autophagy and tumorigenesis.
BECN1-APP (show APP Antibodies) association and BECN1-dependent APP (show APP Antibodies) endocytosis and degradative trafficking were negatively regulated by active AKT (show AKT1 Antibodies).
findings will also clarify the conflict between apoptosis-autophagy on the basis of its unique property derived from surface chemistry modulation, in context of Beclin-1 eminent cleavage/splice which remarks novel effect of Beclin-1 dependent tuning of autophagosomes formation and switch to enhance apoptotic index, mediates by PI3KC3 cleavage and caspase (show CASP3 Antibodies) activation
Data suggest that BECN1 exhibits a helical region that transitions between packing (folding/unfolding) as part of either one of two conserved domains; packing of this helical region appears to have important implications for relative stability of autophagy-inactive and autophagy-active BECN1 complexes.
downregulation of HOXC9 (show HOXC9 Antibodies) releases its transcriptional inhibition of DAPK1 (show DAPK1 Antibodies), resulting in the activation of the DAPK1 (show DAPK1 Antibodies)-Beclin1 pathway, which induces autophagy in glioblastoma cells
ASPP2 (show TP53BP2 Antibodies) is a key regulator of BECN1-dependent autophagy.
the polyQ domain enables wild-type ataxin 3 (show ATXN3 Antibodies) to interact with beclin 1, a key initiator of autophagy; this interaction allows the deubiquitinase activity of ataxin 3 (show ATXN3 Antibodies) to protect beclin 1 from proteasome-mediated degradation and thereby enables autophagy
findings suggest that expression of cFLIPL regulates the basal interaction of Bcl-2 (show BCL2 Antibodies) with Beclin-1 and substantiates p53 (show TP53 Antibodies) dependent ubiquitination of Beclin-1 during autophagic stress to determine the fate of cell death or survival.
Here, sequence analyses, structural modeling, mutagenesis combined with pull-down assays, X-ray crystal structure determination and small-angle X-ray scattering were used to investigate the Beclin 1-GAPR-1 interaction. changes in the structure of the equatorial groove combined with the improved dimerization of pentad mutant GAPR-1 are likely to abrogate binding to Beclin 1.
Acetylated PGK1 (show PGK1 Antibodies) binds to and phosphorylates Beclin1 at S30 (show FAU Antibodies), leading to activation of the VPS34 (show PIK3C3 Antibodies)-Beclin1 complex to initiate autophagosomal formation.
proteostasis regulator cysteamine, which rescues the function of the most common F508del-CFTR (show CFTR Antibodies) mutant and hence reduces lung inflammation in CF patients, can also repair the defects of CF macrophages, thus restoring both bacterial internalization and clearance through a process that involves upregulation of the pro-autophagic protein Beclin 1 and re-establishment of the autophagic pathway.
Genetically disrupting BECN1-BCL2 (show BCL2 Antibodies) binding hyperactivates autophagy in vivo, which sequestrates amyloid oligomers and prevents Alzheimer's disease progression.
Data show that 1-month of oral treatment with beta-asarone reduces AChE, Abeta42, APP (show APP Antibodies) and Beclin-1 levels and alleviates some behavioral impairments by inhibiting the autophagy via regulating the PI3K/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway in APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) transgenic mice. The results further support the exploration of beta-asarone as a possible disease-modifying agent for the treatment of Alzheimer's disease.
identify FAK (show PTK2 Antibodies) as a novel negative regulator of Beclin1-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth
The results not only demonstrate that BECN1 as a PI3K-III component is essential for cytokinesis, but also suggest that BECN1 is not associated with autophagy pathway in mouse oocytes.
this study shows that knockdown of beclin1 enhances macrophage-associated (show CD163 Antibodies) phagocytosis and intracellular killing of Pseudomonas aeruginosa
provide the novel evidence that GADD45A (show GADD45A Antibodies) inhibits autophagy via impairing the BECN1-PIK3C3 (show PIK3C3 Antibodies) complex formation
in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death.
suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling
FBG1 (show FBXO2 Antibodies) degrades A1AT (show SERPINA1 Antibodies)-Z through a Beclin1-dependent arm of autophagy.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR (show FRAP1 Antibodies), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6