Browse our CALCRL Proteins (CALCRL)

Full name:
Calcitonin Receptor-Like Proteins (CALCRL)
On are 7 Calcitonin Receptor-Like (CALCRL) Proteins from 2 different suppliers available. Additionally we are shipping CALCRL Antibodies (54) and CALCRL Kits (7) and many more products for this protein. A total of 74 CALCRL products are currently listed.
list all proteins Gene Name GeneID UniProt
CALCRL 10203 Q16602
CALCRL 54598 Q9R1W5
Rat CALCRL CALCRL 25029 Q63118

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CALCRL Proteins (CALCRL) by Origin

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More Proteins for CALCRL Interaction Partners

Human Calcitonin Receptor-Like (CALCRL) interaction partners

  1. Data suggest CGRP (show S100A12 Proteins) receptor (CGRPR) ECL2 (extracellular loop 2 domain) enables interaction with N-terminal residues of CGRP (show S100A12 Proteins); this provides evidence for dual involvement of ECL2 in two-domain binding model of CGRP (show S100A12 Proteins)/CGRPR interaction; CGRPR is obligate heterodimer of CLR (show DCLK3 Proteins)/RAMP1 (show RAMP1 Proteins). (CGRP (show S100A12 Proteins) = calcitonin gene-related peptide (show CALCA Proteins); CLR (show DCLK3 Proteins) = calcitonin receptor-like receptor; RAMP1 (show RAMP1 Proteins) = receptor [calcitonin (show CALCA Proteins)] activity modifying protein 1)

  2. Mouse and human heart valves expressed mRNAs for the CRL (show IL31RA Proteins) ligands adrenomedullin (show ADM Proteins) (AM), adrenomedullin-2 (AM-2 (show ADM2 Proteins)) and calcitonin gene-related peptide (CGRP (show CALCA Proteins)) and for their receptor components, i.e., CRL (show IL31RA Proteins) and receptor-activity-modifying proteins 1-3.

  3. interaction of RAMP2 (show RAMP2 Proteins) or RAMP3 (show RAMP3 Proteins) with CLR (show DCLK3 Proteins) induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism.

  4. STC1 (show STC1 Proteins) interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition.

  5. Data suggest that ligand binding of a G protein-coupled receptor (GPCR (show TAS1R3 Proteins)) may inform drug development targeting calcitonin receptor-like receptor (CLR):receptor activity-modifying proteins RAMP1 (show RAMP1 Proteins)/2 complexes.

  6. the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR (show DCLK3 Proteins) and RAMP2 (show RAMP2 Proteins), but not RAMP3 (show RAMP3 Proteins), are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus

  7. Two CALCRL variants were associated with risk for gestational diabetes.

  8. Data suggest isoforms of RAMP (receptor activity-modifying protein) modulate accessibility of peptides to residues situated on CALCRL N-terminal domain; RAMP3 (show RAMP3 Proteins)/RAMP2 (show RAMP2 Proteins)/RAMP1 (show RAMP1 Proteins) appear to alter accessibility of specific residues at CALCRL-RAMP interface.

  9. CRLR expression is upregulated in the fetal lung with increasing gestational age.

  10. The G-protein-coupled receptor (show ADRA1A Proteins) CLR (show DCLK3 Proteins) is upregulated in an autocrine loop with adrenomedullin (show ADM Proteins) in clear cell renal cell carcinoma (show MOK Proteins) and associated with poor prognosis.

Mouse (Murine) Calcitonin Receptor-Like (CALCRL) interaction partners

  1. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (show ADM Proteins) (AM), adrenomedullin-2 (AM-2 (show ADM2 Proteins)) and calcitonin gene-related peptide (CGRP (show CALCA Proteins)) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.

  2. these data indicate that the structural integrity of caveolae plays an important role in regulating subcellular distribution of CLR (show CALCR Proteins).

  3. Calcrl deficiency results in multi-organ lymphangiectasia in adult mice.

  4. Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3 (show RAMP3 Proteins), but not of intermedin (IMD (show ADM2 Proteins)), calcitonin receptor-like receptor (CRLR), and RAMP1 (show RAMP1 Proteins) and RAMP2 (show RAMP2 Proteins).

  5. role in cell surface expression of CRLR/RAMP heterodimeric receptors

  6. The Calcrl gene targeted mice provide the first in vivo genetic evidence that Calcitonin receptor (show CALCR Proteins) functions as an Adrenomedullin receptor (show GPR182 Proteins) during embryonic development.

  7. loss of calcrl in endothelial cells confirmed an essential role for AM signaling in vascular development.

  8. CTR (show CALCR Proteins) is not only down regulated by signaling through the CTR (show CALCR Proteins) but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins

Pig (Porcine) Calcitonin Receptor-Like (CALCRL) interaction partners

  1. Data suggest that ADM (adrenomedullin (show ADM Proteins)) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (calcitonin gene-related peptide (show CALCA Proteins) receptor; not adrenomedullin receptor (show GPR182 Proteins)).

Cow (Bovine) Calcitonin Receptor-Like (CALCRL) interaction partners

  1. Data indicate that adrenomedullin (show ADM Proteins) mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR, RAMP2 (show RAMP2 Proteins) and RAMP3 (show RAMP3 Proteins) were detected in cotyledonary villous and caruncular epithelial cells.

CALCRL Protein Profile

Protein Summary

Receptor for calcitonin-gene-related peptide (CGRP) (By similarity). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).

Alternative names and synonyms associated with CALCRL

  • calcitonin receptor-like (CALCRL)
  • calcitonin receptor-like (LOC100168906)
  • calcitonin receptor-like (calcrl)
  • calcitonin receptor-like (Calcrl)
  • AV071593 protein
  • CALCRL protein
  • CGRPR protein
  • CLR protein
  • Crlr protein
  • RATCRLR protein
  • RNCLR protein

Protein level used designations for CALCRL

calcitonin receptor-like , calcitonin gene-related peptide type 1 receptor-like , CGRP type 1 receptor , Calcitonin receptor-like receptor , calcitonin gene-related peptide type 1 receptor , calcitonin receptor-like receptor

459810 Pan troglodytes
488438 Canis lupus familiaris
100391342 Callithrix jacchus
100467118 Ailuropoda melanoleuca
100168906 Acyrthosiphon pisum
100584527 Nomascus leucogenys
549647 Xenopus (Silurana) tropicalis
10203 Homo sapiens
54598 Mus musculus
25029 Rattus norvegicus
379898 Xenopus laevis
423990 Gallus gallus
397172 Sus scrofa
527140 Bos taurus
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