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interaction of RAMP2 (show RAMP2 Proteins) or RAMP3 (show RAMP3 Proteins) with CLR (show DCLK3 Proteins) induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism.
STC1 (show STC1 Proteins) interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition.
Data suggest that ligand binding of a G protein-coupled receptor (GPCR (show TAS1R3 Proteins)) may inform drug development targeting calcitonin receptor-like receptor (CLR):receptor activity-modifying proteins RAMP1 (show RAMP1 Proteins)/2 complexes.
the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR (show DCLK3 Proteins) and RAMP2 (show RAMP2 Proteins), but not RAMP3 (show RAMP3 Proteins), are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus
Two CALCRL variants were associated with risk for gestational diabetes.
Data suggest isoforms of RAMP (receptor activity-modifying protein) modulate accessibility of peptides to residues situated on CALCRL N-terminal domain; RAMP3 (show RAMP3 Proteins)/RAMP2 (show RAMP2 Proteins)/RAMP1 (show RAMP1 Proteins) appear to alter accessibility of specific residues at CALCRL-RAMP interface.
CRLR expression is upregulated in the fetal lung with increasing gestational age.
The G-protein-coupled receptor (show ADRA1A Proteins) CLR (show DCLK3 Proteins) is upregulated in an autocrine loop with adrenomedullin (show ADM Proteins) in clear cell renal cell carcinoma (show MOK Proteins) and associated with poor prognosis.
An alanine scan of residues 271-294 of CLR (show DCLK3 Proteins) showed that the ability of CGRP (show S100A12 Proteins) to produce cAMP was impaired by point mutations at 13 residues; most of these also impaired the response to adrenomedullin (show ADM Proteins) (AM).
The study implicates genetic variation at the CALCRL gene in the pathogenesis of primary angle closure glaucoma in an Australian Caucasian cohort.
these data indicate that the structural integrity of caveolae plays an important role in regulating subcellular distribution of CLR (show CALCR Proteins).
Calcrl deficiency results in multi-organ lymphangiectasia in adult mice.
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3 (show RAMP3 Proteins), but not of intermedin (IMD (show ADM2 Proteins)), calcitonin receptor-like receptor (CRLR), and RAMP1 (show RAMP1 Proteins) and RAMP2 (show RAMP2 Proteins).
role in cell surface expression of CRLR/RAMP heterodimeric receptors
The Calcrl gene targeted mice provide the first in vivo genetic evidence that Calcitonin receptor (show CALCR Proteins) functions as an Adrenomedullin receptor (show GPR182 Proteins) during embryonic development.
loss of calcrl in endothelial cells confirmed an essential role for AM signaling in vascular development.
CTR (show CALCR Proteins) is not only down regulated by signaling through the CTR (show CALCR Proteins) but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins
Data suggest that ADM (adrenomedullin (show ADM Proteins)) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (calcitonin gene-related peptide (show CALCA Proteins) receptor; not adrenomedullin receptor (show GPR182 Proteins)).
Data indicate that adrenomedullin (show ADM Proteins) mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR, RAMP2 (show RAMP2 Proteins) and RAMP3 (show RAMP3 Proteins) were detected in cotyledonary villous and caruncular epithelial cells.
Receptor for calcitonin-gene-related peptide (CGRP) (By similarity). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
, calcitonin gene-related peptide type 1 receptor-like
, CGRP type 1 receptor
, Calcitonin receptor-like receptor
, calcitonin gene-related peptide type 1 receptor
, calcitonin receptor-like receptor