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Both FMRP (show FMR1 Proteins) deficiency in Fmr1 (show FMR1 Proteins)(I304N) mice and Fmr1 (show FMR1 Proteins) knockdown impeded the axonal delivery of miR (show MLXIP Proteins)-181d, Map1b (show MAP1B Proteins), and Calm1 and reduced the protein levels of MAP1B (show MAP1B Proteins) and calmodulin in axons.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.
Data suggest that Cys3602 in RyR2 (ryanodine receptor 2) plays important role in activation/termination of Ca2+ release, but it is not essential for calmodulin regulation of RyR2.
CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling.
Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons.
Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail.
Using mass spectrometry this study identified calmodulin as a calcium-dependent GluN2A (show GRIN2A Proteins) binding partner.
new insights into the role of BTK (show BTK Proteins), an important target for autoimmune diseases, in B cell activation (show BLNK Proteins)
The relationships between the interaction of alphaCaMKII with CaM and the conformational change of alphaCaMKII, were investigated.
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).
, Calmodulin 1 (phosphorylase kinase, delta)