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Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.
Data suggest that Cys3602 in RyR2 (ryanodine receptor 2) plays important role in activation/termination of Ca2+ release, but it is not essential for calmodulin regulation of RyR2.
CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling.
Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons.
Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail.
Using mass spectrometry this study identified calmodulin as a calcium-dependent GluN2A (show GRIN2A Proteins) binding partner.
new insights into the role of BTK (show BTK Proteins), an important target for autoimmune diseases, in B cell activation (show BLNK Proteins)
The relationships between the interaction of alphaCaMKII with CaM and the conformational change of alphaCaMKII, were investigated.
the conformational changes of calmodulin (show KRIT1 Proteins) upon Ca(2 (show CA2 Proteins)+) and mastoparan binding
MLCK and calmodulin (CaM) co-purify with unphosphorylated SMM from chicken gizzard, suggesting that they are tightly bound.
Insights from structural proteomics can be used to generate CaM-insensitive mutants of CaM targets for functional studies in vitro or ideally in vivo.
The unique C terminus of the calcineurin isoform CNAbeta1 confers non-canonical regulation of enzyme activity by Ca(2+) and calmodulin
The main functional derangement in CALM1-F142L was prolonged repolarization with altered rate-dependency and sensitivity to beta-adrenergic stimulation.
These results reveal that mTOR is a new type of calmodulin-dependent kinase, and TRPML1, lysosomal calcium and calmodulin play essential regulatory roles in the mTORC1 signaling pathway.
The structural basis for the recognition of EEF2K by calmodulin has been presented.
irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU (show CALU Proteins), and RCN1 (show RCAN1 Proteins), suggesting important roles for these mediators in promoting irradiated tumor cell survival during hypoxia
Calcium modulates calmodulin-ACTN1 (show ACTN1 Proteins) interaction with and agonist-dependent internalization of the adenosine A2A receptor (show ADORA2A Proteins).
Data suggest that GRB10 (show GRB10 Proteins) and GRB14 (show GRB14 Proteins) are both Ca2 (show CA2 Proteins)+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 (show GRB10 Proteins) and GRB14 (show GRB14 Proteins), as compared to a single one present in GRB7 (show GRB7 Proteins). (GRB10 (show GRB10 Proteins) = growth factor receptor-bound protein 10 (show GRB10 Proteins); GRB14 (show GRB14 Proteins) = growth factor receptor-bound protein 14 (show GRB14 Proteins); CaM = calmodulin; GRB7 (show GRB7 Proteins) = growth factor receptor-bound protein 7 (show GRB7 Proteins))
studies demonstrate that UBE3B (show UBE3B Proteins) is an E3 ubiquitin ligase (show MUL1 Proteins) and reveal that the enzyme is regulated by calmodulin. Furthermore, the modulation of UBE3B (show UBE3B Proteins) via calmodulin and calcium implicates a role for calcium signaling in mitochondrial protein (show COX6B2 Proteins) ubiquitylation, protein turnover, and disease
Up-regulation of miR (show MLXIP Proteins)-335 suppressed CaM protein expression in patients with acute ischemic stroke, and CaM was confirmed as a direct target of miR (show MLXIP Proteins)-335.
analysis of CaM docked to a functioning KCNQ K(+) channel (KCNQ2 and KCNQ3) [KCNQ2, KCNQ3]
Asp-CaM complex has a critical role in centrosome-pole cohesion and centrosome inheritance in neural stem cells
Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does.
characterized the interdomain motions in the calcium-bound state of calmodulin (Ca(2+)-CaM) using NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations
Regulatory implications of a novel mode of interaction of calmodulin with a double IQ-motif target sequence from murine dilute myosin V (show MYO5A Proteins).
null behavioral phenotype originates in the nervous system and involves a calmodulin function that requires calcium binding to all four sites of the protein
the direct interaction of melatonin with intact calcium-saturated CaM is calcium-dependent; Molecular dynamics simulations follow the dynamics of melatonin in the binding pocket of CaM
potential functional role for calmodulin in regulation of the glycolytic pathway
A mutation to the gene encoding calmodulin deregulates muscle contraction.
Drosophila CaM is able to fully activate inducible nitric oxide synthase (iNOS (show NOS2 Proteins)); moreover, iNOS (show NOS2 Proteins) activation by CaM, like neuronal NOS (show NOS1 Proteins), is not dependent on Ca2 (show CA2 Proteins)+ being bound to all four Ca2 (show CA2 Proteins)+-binding sites, but has specific and distinct requirements.
Calmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2 (show CA2 Proteins)+)-stimulating G protein-coupled receptor (show GPBAR1 Proteins), which could prevent cell damage due to extra Ca(2 (show CA2 Proteins)+) influx.
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
, Calmodulin 1 (phosphorylase kinase, delta)
, calmodulin 2
, calmodulin 3
, calmodulin 1 (phosphorylase kinase, delta)
, phosphorylase kinase subunit delta
, phosphorylase kinase, delta subunit
, prepro-calmodulin 1
, Calmodulin-2 A
, Calmodulin-2 B
, CG8472 gene product from transcript CG8472-RC
, CaM Gamma 2