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Browse our CCR2 Proteins (CCR2)

Full name:
Chemokine (C-C Motif) Receptor 2 Proteins (CCR2)
On www.antibodies-online.com are 5 Chemokine (C-C Motif) Receptor 2 (CCR2) Proteins from 3 different suppliers available. Additionally we are shipping CCR2 Antibodies (280) and CCR2 Kits (13) and many more products for this protein. A total of 307 CCR2 products are currently listed.
Synonyms:
Cc-ckr-2, CCR-2, Ccr2a, Ccr2b, CD192, Ckr2, Ckr2a, Ckr2b, Cmkbr2, MCP-1-R, mJe-r
list all proteins Gene Name GeneID UniProt
CCR2 729230 P41597
CCR2 12772 P51683
Rat CCR2 CCR2 60463 O55193

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CCR2 Proteins (CCR2) by Origin

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Top referenced CCR2 Proteins

  1. Human CCR2 Protein expressed in Wheat germ - ABIN1329948 : Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014 (PubMed)

More Proteins for CCR2 Interaction Partners

Human Chemokine (C-C Motif) Receptor 2 (CCR2) interaction partners

  1. High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes.

  2. X ray crystal structure of CC chemokine receptor 2 (show CCRL2 Proteins) with orthosteric and allosteric antagonists

  3. Ingestion of an amino acid supplement immediately post-exercise appears to help maintain plasma MCP-1 concentrations and augment CCR2 expression in resistance trained men.

  4. HUMSCs expressing ISZ-sTRAIL might be an efficient therapeutic approach against lung cancer and MCP-1/CCR2 axis is essential for the tumor tropism of HUMSCs

  5. The authors demonstrate a positive correlation between CCR2 receptor gene polymorphism and a subgroup of breast cancer showing poor prognosis, which deserves further investigation in larger samples for validation.

  6. Results of this study indicated that the CCL2-CCR2 axis was involved in the pathogenesis of oral lichen planus and was positively correlated with disease activity.

  7. sCCL2 production possibly will be associated with the adiposity and polymorphic phenotypes of CCL2 (show CCL2 Proteins) and CCR2, in Mexican-Mestizos with insulin (show INS Proteins) resistance

  8. Increased CCR2 expression is associated with bladder cancer metastasis.

  9. These findings suggested that the CCL2 (show CCL2 Proteins)/CCR2 chemokine (show CCL1 Proteins) signaling may regulate the epithelial-mesenchymal transition.

  10. CCR2 gene polymorphism (64I allele carriage) is a predisposing factor for allergy.

Mouse (Murine) Chemokine (C-C Motif) Receptor 2 (CCR2) interaction partners

  1. The results indicate that CCR2 plays an essential role in Helicobacter pylori-induced immune tolerance and shed light on a novel mechanism of CCR2-dependent dendritic cell Treg cell induction, which appears to be important in maintaining mucosal homeostasis during Helicobacter pylori infection.

  2. CCR2(-/-) resident cardiac Macrophage favor a more antiinflammatory phenotype relative to WT controls

  3. Endothelial VCAM-1 targeted delivery of the CCR2 antagonist resulted in inhibition of pulmonary metastases both in a murine (MC-38GFP cells) and a human xenograft (patient-derived cells) model.

  4. To interrogate the role of CCR2 activation on Nf1 (show NF1 Proteins)(+/-) neointima formation, authors induced neointima formation by carotid artery ligation in Nf1 (show NF1 Proteins)(+/-) and WT mice with genetic deletion of either MCP1 (show CCL2 Proteins) or CCR2. Loss of MCP-1 (show CPT1B Proteins) or CCR2 expression effectively inhibited Nf1 (show NF1 Proteins)(+/-) neointima formation and reduced macrophage content in the arterial wall.

  5. involved in Staphylococcus aureus-induced MCP-1 (show CPT1B Proteins) production via NF-kB or p38-MAPK (show MAPK14 Proteins) signaling

  6. CCL2 and its receptor CCR2 are important for the formation of osteoclasts and foreign body giant cells.

  7. Disruption of CCR2 enhanced tau pathology and reduced cavity volume in mild traumatic brain injury.

  8. In the absence of the rd8 allele, deficiency of CCR2 and CX3CL1 (show CX3CL1 Proteins) in mice leads to a mild form of retinal degeneration which is associated with the recruitment of macrophages, particularly to the subretinal space. This model enables to assess consequences of perturbed chemokine (show CCL1 Proteins) signaling, but it does not recapitulate cardinal (show CARD8 Proteins) age-related macular degeneration features.

  9. The results indicate that AMPK (show PRKAA1 Proteins) is a negative regulator of Ccr2 expression in RAW264.7 macrophages, and that the mechanism of action of AMPK (show PRKAA1 Proteins) inhibition of Ccr2 is mediated, in part, through the NF-kappaB (show NFKB1 Proteins) pathway.

  10. upon binding to a composite NFAT (show NFATC1 Proteins)/BCL6 (show BCL6 Proteins) regulatory element within the Ccl2 (show CCL2 Proteins) promoter, NFATc1 (show NFATC1 Proteins)/beta proteins release the BCL6 (show BCL6 Proteins)-dependent repression of Ccl2 (show CCL2 Proteins) gene in macrophages.

CCR2 Protein Profile

Protein Summary

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

Alternative names and synonyms associated with CCR2

  • chemokine (C-C motif) receptor 2 (CCR2)
  • chemokine (C-C motif) receptor 2 (Ccr2)
  • Cc-ckr-2 protein
  • CCR-2 protein
  • Ccr2a protein
  • Ccr2b protein
  • CD192 protein
  • Ckr2 protein
  • Ckr2a protein
  • Ckr2b protein
  • Cmkbr2 protein
  • MCP-1-R protein
  • mJe-r protein

Protein level used designations for CCR2

C-C chemokine receptor type 2 , MCP-1 receptor , monocyte chemoattractant protein 1 receptor , monocyte chemotactic protein 1 receptor , C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR) , C-C CKR-2 , CCR-2 , JE/FIC receptor , MIP-1 alphaR , chemoattractant protein-1 receptor , chemokine (C-C) receptor 2 , CC-CKR-2 , chemokine receptor CCR2 , MCP-1-R , chemokine receptor

GENE ID SPECIES
729230 Homo sapiens
12772 Mus musculus
60463 Rattus norvegicus
484790 Canis lupus familiaris
574098 Macaca mulatta
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