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Human CCR2 Protein expressed in Wheat germ - ABIN1329948
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
The CCR2 (+190 G/A) GG genotype frequencies for patients were significantly higher in the stage III-IV cancer group ( p = 0.036), and A allele carriers were significantly higher in the stage I-II ovarian cancer group.
tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment
The findings of the work indicate a role for Galphaq (show GNAQ Proteins) and/or Galpha14 and in CCR2a/CCR2b-stimulated Rho A (show RHOA Proteins) GTPase (show RACGAP1 Proteins)-mediated serum response factor activation.
Endogenous TRAIL/TRAIL-R-mediated CCL2 (show CCL2 Proteins) secretion promotes accumulation of tumor-supportive immune cells in the cancer microenvironment.
CCL2 (show CCL2 Proteins)/CCR2 axis is expressed in the majority of monocytoid Acute myeloid leukemia (show BCL11A Proteins) blasts
CCR2B and beta2AR (show ADRB2 Proteins) signals to FLNa (show FLNA Proteins) to stimulate its endocytosis and recycling to the plasma membrane.
this study shows that CYTL1 (show CYTL1 Proteins) possesses chemotactic activity and demonstrates that its functional receptor is CCR2B
PCSK9 regulates monocyte CCR2 expression and chemotaxis.
CCR2-targeted therapy with PF-04136309 in combination with FOLFIRINOX is safe and tolerable
Binding of J113863 to CCR2 or CCR5 also induced the recruitment of beta-arrestin 2, whereas UCB35625 did not. UCB35625 induced the chemotaxis of L1.2 cells expressing CCR2 or CCR5. In contrast, J113863 induced the migration of L1.2-CCR2 cells but antagonized the chemokine-induced migration of L1.2-CCR5 cells.
in vitro and in vivo results show that CCR2 intrinsically mediates the expression of inflammatory T cell cytokines, and its absence on T cells results in attenuated colitis progression
CCR2 expression on bone marrow-derived cells, likely macrophages, is essential to muscle regeneration independent of TLR signaling, aging, and sex.
we demonstrated that CX3CR1 (show CX3CR1 Proteins)(Lo)CCR2(Hi) monocytes were recruited to the GBM, where they transitioned to CX3CR1 (show CX3CR1 Proteins)(Hi)CCR2(Lo) macrophages and CX3CR1 (show CX3CR1 Proteins)(Hi)CCR2(-) microglia-like cells. Infiltrating macrophages/monocytes constituted approximately 85% of the total TAM (show CCNA1 Proteins) population, with resident microglia accounting for the approximately 15% remaining.
we characterized a novel regulatory network in macrophages, in which CCR2 activates PI3K-AKT (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) signaling to mediate HIF-1alpha (show HIF1A Proteins) expression, which then drives VEGF-C (show VEGFC Proteins) expression to promote lymphangiogenesis.
CXCR4 (show CXCR4 Proteins), CCR2, and CX3CR1 (show CX3CR1 Proteins) direct dendritic cell precursors from the bone marrow to the lung differentially.
The findings suggest that CCR2 deficiency does not provide a sustained benefit and that Ly6C(low) macrophages may contribute to the progressive fibrosis and dysfunction of mdx (show DMD Proteins)(5cv) diaphragm.
In Ccr2(-/-) mice, a damaged microglia recruitment was shown in retina and this could protect the visual function in electroretinogram and alleviate the photoreceptor apoptosis.
This study establishes ECL1i as the first allosteric inhibitor of CCR2 with functional selectivity.
the individual and combined actions of CCL2 (show CCL2 Proteins)/CCR2 and CX3CL1 (show CX3CL1 Proteins)/CX3CR1 (show CX3CR1 Proteins) in hypoxia-induced pulmonary hypertension in mice, is reported.
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
C-C chemokine receptor type 2
, MCP-1 receptor
, monocyte chemoattractant protein 1 receptor
, monocyte chemotactic protein 1 receptor
, C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)
, C-C CKR-2
, JE/FIC receptor
, MIP-1 alphaR
, chemoattractant protein-1 receptor
, chemokine (C-C) receptor 2
, chemokine receptor CCR2
, chemokine receptor