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Browse our CXCR2 Proteins (CXCR2)

Full name:
Chemokine (C-X-C Motif) Receptor 2 Proteins (CXCR2)
On are 8 Chemokine (C-X-C Motif) Receptor 2 (CXCR2) Proteins from 5 different suppliers available. Additionally we are shipping CXCR2 Antibodies (271) and CXCR2 Kits (36) and many more products for this protein. A total of 327 CXCR2 products are currently listed.
CD128, CD182, CDw128, CDw128b, Cmkar2, CXC-R2, CXCR-2, Gpcr16, IL-8rb, IL-8Rh, IL8R2, IL8RA, Il8rb, mIL-8RH
list all proteins Gene Name GeneID UniProt
CXCR2 3579 P25025
CXCR2 12765 P35343
Rat CXCR2 CXCR2 29385 P35407

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CXCR2 Proteins (CXCR2) by Origin

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Top referenced CXCR2 Proteins

  1. Human CXCR2 Protein expressed in Wheat germ - ABIN1330037 : Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014 (PubMed)

More Proteins for CXCR2 Interaction Partners

Human Chemokine (C-X-C Motif) Receptor 2 (CXCR2) interaction partners

  1. we identified novel pathways associated with GPI (show GNPDA1 Proteins)-AP- granulocytes by RNA-seq and validated higher CXCR2 expression in GPI (show GNPDA1 Proteins)-AP- than GPI (show GNPDA1 Proteins)-AP+ granulocytes.

  2. Results identify the CXCL2 (show CXCL2 Proteins)/MIF (show AMH Proteins)-CXCR2 axis as an important mediator in MDSC recruitment and as predictors in bladder cancer.

  3. The analysis of IL-8 (interleukin-8 (show IL8 Proteins)), CXCR1 (IL-8RA (show CXCR1 Proteins) - IL-8 receptor (show CXCR1 Proteins) alpha) and CXCR2 (IL-8RB - IL-8 receptor (show CXCR1 Proteins) beta) expression showed that these molecules are present not only in many different types of inflammatory and endothelial cells, but also in several tumor basaloid, transitional and even few ghost cells.

  4. Study shows that CXCR2 signaling in the myeloid compartment is tumor promoting and required for pancreatic cancer metastasis.

  5. The usefulness of CXCR-2 as potential tumor marker of esophageal cancer was studied.

  6. this study shows that downregulation of CD182 (show CXCR3 Proteins) after stimulation with IL-8 (show IL8 Proteins) is more pronounced in adults than in neonates, whereas fMLP (show FPR1 Proteins) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults

  7. findings present that miR (show MLXIP Proteins)-940 acts as a pivotal adaptor of CXCR2 and its transcription downregulated CXCR2 expression to decrease HCC (show FAM126A Proteins) invasion and migration in vitro.

  8. Our findings suggest that CXCL3 (show CXCL3 Proteins) and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis.

  9. Data suggest that neutrophil-activating peptide 2 (NAP-2 (show PPBP Proteins)) secreted by NK cells can bind to CXC Chemokine Receptor (show CXCR4 Proteins) 2 (CXCR2) on mesenchymal stem cells (MSCs) leading to stimulation of its recruitment.

  10. High CXCR2 expression is associated with pancreatic cancer.

Cow (Bovine) Chemokine (C-X-C Motif) Receptor 2 (CXCR2) interaction partners

  1. Results also demonstrated that in CXCR2 (show CXCR1 Proteins), genotypes BC, CC and FF were probably relevant with mastitis and the genotypes AA, AB and EE may have better milk quality.

Mouse (Murine) Chemokine (C-X-C Motif) Receptor 2 (CXCR2) interaction partners

  1. this study shows that astragaloside IV alleviates E. coli-caused peritonitis through modulating GRK2 (show ADRBK1 Proteins)-CXCR2 signal in neutrophils

  2. Study shows that CXCR2 signaling in the myeloid compartment is tumor promoting and required for pancreatic cancer metastasis.

  3. CXCR2/CXCL1 (show CXCL1 Proteins) axis promotes granulocytic myeloid-derived suppressor cells recruitment and facilitates arginase I (show ARG1 Proteins) expression and activity of these cells at maternal-fetal interface

  4. CXCR2 plays a critical role in particle-induced osteolysis.

  5. This study demonstated that endothelial CXCR2 play essential roles in cerebral endothelial activation and subsequent leukocyte recruitment during neuroinflammation.

  6. Studied DC-specific TLR4 (show TLR4 Proteins) signaling on host defense against intra-abdominal polymicrobial sepsis; found TLR4 (show TLR4 Proteins) deletion on DCs was associated with lower levels of IL-10 (show IL10 Proteins), higher PMN (show TBCE Proteins) accumulation in the peritoneal cavity, and higher expression of CXCR2.

  7. CXCL1 (show CXCL1 Proteins) monomer-dimer distribution and receptor interactions are highly coupled and regulate neutrophil trafficking and that injury in the context of disease is a consequence of inappropriate CXCR2 activation

  8. p53 (show TP53 Proteins)-mediated induction of PAI-1 (show SERPINE1 Proteins) expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1 (show CXCL1 Proteins), CXCL2 (show CXCL2 Proteins), and CXCR2.

  9. Suggest chemotherapy-specific differential regulation of CXCR2 ligands, stem cell-like and mesenchymal phenotypes, and enhanced metastasis in drug-resistant cells and targeting CXCR2 signaling, may help circumvent therapy resistance in breast cancer.

  10. Serum amyloid A1alpha induces paracrine IL-8/CXCL8 (show IL8 Proteins) via TLR2 and directly synergizes with this chemokine (show CCL1 Proteins) via CXCR2 and formyl peptide receptor 2 (show FPR2 Proteins) to recruit neutrophils.

CXCR2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with CXCR2

  • chemokine (C-X-C motif) receptor 2 (Cxcr2)
  • chemokine (C-X-C motif) receptor 2 (CXCR2)
  • chemokine (C-X-C motif) receptor 2 (IL8RB)
  • interleukin 8 receptor, beta (CXCR2)
  • CD128 protein
  • CD182 protein
  • CDw128 protein
  • CDw128b protein
  • Cmkar2 protein
  • CXC-R2 protein
  • CXCR-2 protein
  • Gpcr16 protein
  • IL-8rb protein
  • IL-8Rh protein
  • IL8R2 protein
  • IL8RA protein
  • Il8rb protein
  • mIL-8RH protein

Protein level used designations for CXCR2

C-X-C chemokine receptor type 2 , interleukin 8 receptor beta , interleukin-8 receptor CXCR2 , CXC-R2 , CXCR-2 , CXCR2 gene for IL8 receptor type B , GRO/MGSA receptor , IL-8 receptor type 2 , IL-8R B , chemokine (CXC) receptor 2 , high affinity interleukin-8 receptor B , interleukin 8 receptor B , interleukin 8 receptor type 2 , interleukin 8 receptor, beta , interleukin-8 receptor type B , chemokine receptor CXCR2 , interleukin 8 receptor, alpha , IL-8 receptor alpha chain , chemokine (C-X-C) receptor 2 , IL-8 receptor , High affinity interleukin-8 receptor B , interleukin-8 receptor, beta

100379569 Cavia porcellus
3579 Homo sapiens
782719 Bos taurus
12765 Mus musculus
100328627 Oryctolagus cuniculus
29385 Rattus norvegicus
700407 Macaca mulatta
470644 Pan troglodytes
478905 Canis lupus familiaris
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