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melanocortin receptors MC2R (show MC2R ELISA Kits), MC3R (show MC3R ELISA Kits) and MC5R are most abundantly expressed in glandular epithelium of the endometrium
MC2R (show MC2R ELISA Kits) and MC1R (show MSHR ELISA Kits) signals are consecutively required for the regulation of EPO (show EPO ELISA Kits) signal transduction in erythroblast differentiation, and MC5R signal transduction is required to induce enucleation.
D115 and D119 in TM3 (show TPM1 ELISA Kits), F195 in TM5, and F254 in TM6 may form a binding pocket for NDP (show NDP ELISA Kits)-alpha-MSH binding.
Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK (show MAPK1 ELISA Kits) pathway and beta-arrestins 1/2.
Data suggest that antagonists of MC1R (show MSHR ELISA Kits) and MC5R could be effective inhibitors of sebaceous gland differentiation and the production of sebum-specific lipids.
Variations in the melanocortin 5 receptor gene are unlikely to confer susceptibility to bipolar disorder in this sample.
Further structure-activity studies of lactam derivatives of MT-II (show MT2 ELISA Kits) and SHU-9119 were made at MC5R.
MC5R signals through a PI3K (show PIK3CA ELISA Kits)-regulated Akt (show AKT1 ELISA Kits)-independent pathway leading to downstream activation of ERK1/2 (show MAPK1/3 ELISA Kits)
MC5r-dependent regulatory immunity increased CD11b (show ITGAM ELISA Kits)(+)F4/80(+)Ly-6C(low)Ly-6G(+)CD39 (show ENTPD1 ELISA Kits)(+)CD73(+) APCs (show APCS ELISA Kits) in the spleen of post-experimental autoimmune uveoretinitis mice.
In 3T3-L1 adipocytes, alpha-MSH-activated MC5-R signals through the cAMP/PKA and MAPK (show MAPK1 ELISA Kits)/ERK1/2 (show MAPK1/3 ELISA Kits) pathways.
Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
Dependence on MC5r expression promotes or selectively activates IRBP (show RBP3 ELISA Kits)-specific FoxP3 (show FOXP3 ELISA Kits)+ TGF-beta (show TGFB1 ELISA Kits)+ CD25 (show IL2RA ELISA Kits)+CD4 (show CD4 ELISA Kits)+ Treg cells in the spleens of experimental uveitis-recovered mice.
melanocortin 2 receptor (show MC2R ELISA Kits) and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes
Data show that melanocortins regulate Il6 (show IL6 ELISA Kits) gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.
The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor (show MC2R ELISA Kits) but disrupting dimerization and surface localization of MC5 receptor.
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.
, melanocortin receptor 5
, G-protein-coupled receptor
, melanocortin 5 receptor
, melanocortin 1 receptor Mc1r
, melanocortin-5 receptor