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Browse our Neurofibromin 1 Proteins (NF1)

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Neurofibromin 1 Proteins (NF1)
On are 3 Neurofibromin 1 (NF1) Proteins from 3 different suppliers available. Additionally we are shipping Neurofibromin 1 Antibodies (127) and Neurofibromin 1 Kits (6) and many more products for this protein. A total of 140 Neurofibromin 1 products are currently listed.
AW494271, CG8318, Dmel\\CG8318, dNF1, E030030H24Rik, fe06d03, hm:zehn0874, Nf-1, nf1, NFNS, VRNF, WSS, wu:fe06d03, zehn0874
list all proteins Gene Name GeneID UniProt
Mouse NF1 NF1 18015 Q04690
NF1 4763 P21359
Rat NF1 NF1 24592 P97526

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Neurofibromin 1 Proteins (NF1) by Origin

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Top referenced Neurofibromin 1 Proteins

  1. Human Neurofibromin 1 Primary Antibody for AP, AA - ABIN1312428 : Kweh, Zheng, Kurenova, Wallace, Golubovskaya, Cance: Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. in Molecular carcinogenesis 2009 (PubMed)

More Proteins for Neurofibromin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Neurofibromin 1 (NF1) interaction partners

  1. Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.

  2. The N-terminal region of NF1 mediates the interaction with Fak56 and is required for the signaling activity and presynaptic localization of NF1

  3. These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk as a potential therapeutic target in NF1

  4. memory-related functions of Rut (show ADCY5 Proteins)-AC are both Nf1-dependent and -independent, that Nf1 mediates the formation of two distinct memory components within a single neuron population.

  5. survival of a subset of midline glia cells depends upon direct suppression of the proapoptotic protein HID via the EGF receptor (show EGFR Proteins)/RAS/MAPK (show MAPK1 Proteins) pathway

  6. role in insulin (show INS Proteins)-mediated proliferation of Schneider cells

  7. preliminary crystallographic characterization of a novel segment (homologous to the yeast Sec14p lipid exchange protein) from the neurofibromatosis type 1 protein

  8. Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras

  9. Loss of NF1 can give rise to non-cell-autonomous developmental defects, implicate aberrant Ras-mediated signaling in larval neurons as the primary cause of the NF1 growth deficiency.

  10. Neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS (show ROS1 Proteins) production, and NF1 may be treatable using catalytic antioxidants.

Cow (Bovine) Neurofibromin 1 (NF1) interaction partners

  1. DNA variants in the NF1 gene are associated with genetic disposition to bovine spongiform encephalopathy.

Zebrafish Neurofibromin 1 (NF1) interaction partners

  1. study shows negative regulation of Ras (show RAB1A Proteins) pathway through GAP activity of NF1 limits oligodendrocyte progenitor cell (OPC) proliferation and motility during development; provides insight into oncogenic mechanisms by which NF1 loss contributes to glial tumors

  2. identification and characterization of nf1a and nf1b, orthologues of NF1, that show neural crest and cardiovascular defects resulting from morpholino knockdown, including vascular and cardiac valvular abnormalities

Mouse (Murine) Neurofibromin 1 (NF1) interaction partners

  1. Spatially- and temporally-controlled postnatal p53 (show TP53 Proteins) knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.

  2. These findings demonstrate a role for Ras-GAP (show RASA1 Proteins) activity in suppressing the hemogenic potential of the heart and restricting growth of neural crest-derived tissues.

  3. identified p21Ras-dependent hyperphosphorylation of Pu.1 within the nucleus of Nf1 haploinsufficient myelomonocytic osteoclast precursors, providing a novel therapeutic target for the potential treatment of NF1 associated osteolytic manifestations.

  4. Targeted gene deletion of TP53 (show TP53 Proteins), Pten, and NF1 in mouse brain causes glioblastoma.

  5. Data indicated a critical role for Nf1 in regulating multiple mesenchymal stem/progenitor cells functions, including migration and adhesion through both the PI3-K (show PIK3CA Proteins) and MAPK (show MAPK1 Proteins) pathways.

  6. this is the first demonstration that different germline NF1 gene mutations differentially dictate neurofibromin function in the brain.

  7. Data suggest that bi-allelic loss of Nf1 induces autonomous adrenal hyper-activity. Nf1 seems involved in the regulation of adrenal cortex function in mice and humans.

  8. FGFR1 (show FGFR1 Proteins) signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP (show RASA1 Proteins) neurofibromin during endochondral bone formation

  9. Low levels of NF1 expression were associated with primary and acquired resistance of lung adenocarcinomas to EGFR (show EGFR Proteins) Thymidine Kinase (show TK1 Proteins) Inhibitors in patients.

  10. eurofibromin differentially controls neural stem cell (NSC) proliferation and multilineage differentiation through the selective use of the PI3K/AKT (show AKT1 Proteins) and RAF (show RAF1 Proteins)/MEK (show MDK Proteins) pathways

Human Neurofibromin 1 (NF1) interaction partners

  1. the results from our work show that the molecular basis of NF1 splicing mutations is diverse. Therefore, molecular characterization at both the gDNA and mRNA levels allowed for a better understanding of gDNA-mRNA correlations of NF1 mutations.

  2. Results suggest that the Neurofibromatosis 1-Noonan syndrome (NFNS) phenotype may be the result of both a genetic factor of mutation in the neurofibromin 1 gene (NF1) and an epigenetic/environmental factor.

  3. The findings of this study suggest that the most childhood NF1-associated low-grade gliomas are midline and benign in nature, hemispheric NF1-related gliomas may have a more aggressive biological and clinical behavior.

  4. The use of Next Generation Sequencing has proven to be effective as for costs, and time for analysis, and it allowed us to identify a patient with NF1 mosaicism.

  5. Her-2 (show ERBB2 Proteins), N-ras (show NRAS Proteins) and Nf1 have roles in brain onocogenesis

  6. A significant correlation between neurofibromin expression and colorectal tumor localization was found, with tumors arising in the colon showing intense NF expression more often than those arising in the rectum; higher expression of NF was more common in tumors not responding to treatment; and tumors with multiple metastases showed higher expression of NF than those with single metastasis

  7. mutation in the NF1 gene is associated with Neurofibromatosis-Noonan Syndrome.

  8. the computational model results have added credibility to the experimental hypothesis of a genetic cause (i.e. Nf1 mutation) for Congenital pseudarthrosis of the tibia

  9. The pattern of growth differs substantially in deletion and non-deletion neurofibromatosis 1 patients, but the pathogenic basis for this difference is unknown.

  10. Fine mapping of meiotic NAHR-associated crossovers causing large NF1 deletions has been reported.

Neurofibromin 1 (NF1) Protein Profile

Protein Summary

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

Alternative names and synonyms associated with Neurofibromin 1 (NF1)

  • neurofibromin 1 (NF1)
  • Neurofibromin 1 (Nf1)
  • neurofibromin 1a (nf1a)
  • neurofibromin (NF1)
  • neurofibromin (AaeL_AAEL008371)
  • neurofibromin (CpipJ_CPIJ011774)
  • neurofibromin (Smp_148460)
  • neurofibromin (LOC100349438)
  • neurofibromatosis 1 (Nf1)
  • neurofibromin 1 (Nf1)
  • AW494271 protein
  • CG8318 protein
  • Dmel\\CG8318 protein
  • dNF1 protein
  • E030030H24Rik protein
  • fe06d03 protein
  • hm:zehn0874 protein
  • Nf-1 protein
  • nf1 protein
  • NFNS protein
  • VRNF protein
  • WSS protein
  • wu:fe06d03 protein
  • zehn0874 protein

Protein level used designations for Neurofibromin 1 Proteins (NF1)

neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) , CG8318-PB , CG8318-PC , CG8318-PD , CG8318-PE , CG8318-PF , Neurofibromatosis-1 , Nf1-PB , Nf1-PC , Nf1-PD , Nf1-PE , Nf1-PF , neurofibramatosis-1 , neurofibromatosis 1 , neurofibromatosis factor 1 , neurofibromatosis type 1 , neurofibromin , neurofibromin 1 , neurofibromin-like , neurofibromatosis-related protein NF-1 , Neurofibromatosis type 1

100071896 Equus caballus
43149 Drosophila melanogaster
280877 Bos taurus
326708 Danio rerio
454566 Pan troglodytes
493675 Felis catus
531372 Bos taurus
593418 Strongylocentrotus purpuratus
100023872 Monodelphis domestica
100392547 Callithrix jacchus
100482656 Ailuropoda melanoleuca
100546215 Meleagris gallopavo
100603967 Nomascus leucogenys
712911 Macaca mulatta
5570549 Aedes aegypti
6045114 Culex quinquefasciatus
8341839 Schistosoma mansoni
100349438 Oryctolagus cuniculus
18015 Mus musculus
4763 Homo sapiens
24592 Rattus norvegicus
100730274 Cavia porcellus
396085 Gallus gallus
480618 Canis lupus familiaris
100526136 Sus scrofa
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